6-甲氧基-1-甲基-1,3-二氢-2H-苯并咪唑-2-酮 | 15965-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 6-甲氧基-1-甲基-1,3-二氢-2H-苯并咪唑-2-酮
• 英文名称: 6-Methoxy-1-methyl-benzimidazolon-(2)
• 英文别名: 6-methoxy-1-methyl-1,3-dihydro-benzoimidazol-2-one；6-Methoxy-1-methyl-1H-benzo[d]imidazol-2(3H)-one；5-methoxy-3-methyl-1H-benzimidazol-2-one
• CAS: 15965-70-5
• 化学式: C₉H₁₀N₂O₂
• 分子量: 178.191
• InChiKey: UYRGCEBXOCYGKP-UHFFFAOYSA-N

物化性质

• 密度：
  1.219±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] COMPOSÉS QUINAZOLINONES ET LEURS DÉRIVÉS
  申请人：AMGEN INC

  公开号：WO2014036022A1

  公开（公告）日：2014-03-06

  Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  公式I的化合物是坦克酶的有用抑制剂。公式I的化合物具有以下结构：其中变量的定义在此提供。
• HETEROCYCLIC COMPOUNDS AS B-RAF INHIBITORS FOR TREATMENT OF CANCER
  申请人：Siddiqui M. Arshad

  公开号：US20140323519A1

  公开（公告）日：2014-10-30

  This invention relates to novel heterocyclic compounds that are useful for treating cancer and other cellular proliferative diseases and/or disorders associated with B-Raf activity. The compounds of the invention may be illustrated by the Formula (I). (Formula (I))

  本发明涉及一种新型杂环化合物，可用于治疗癌症和与B-Raf活性相关的其他细胞增殖性疾病和/或疾病。该发明的化合物可以用式(I)表示。 (式(I))
• Quinazolinone Compounds and Derivatives Thereof
  申请人：AMGEN INC.

  公开号：US20150225396A1

  公开（公告）日：2015-08-13

  Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  公式I的化合物是坦克酰酶的有用抑制剂。公式I的化合物具有以下结构：其中变量的定义在此提供。
• THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2212318B1

  公开（公告）日：2013-07-24
• Thiazole Derivatives as Protein Kinase Inhibitors
  申请人：Reddy Panduranga Adulla P.

  公开号：US20100331313A1

  公开（公告）日：2010-12-30

  The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.