Methyl 6-methyl-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate | 312735-21-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Methyl 6-methyl-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• 英文别名: methyl 6-methyl-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-5-carboxylate
• CAS: 312735-21-0
• 化学式: C₁₆H₂₀N₂O₅S
• 分子量: 352.411
• InChiKey: AYYVPDXJVSMPST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2,4,5-三甲氧基苯甲醛 、 乙酰乙酸甲酯 、 硫脲 在 perchloric acid adsorbed on silica gel 作用下， 反应 3.0h， 以88%的产率得到Methyl 6-methyl-2-sulfanylidene-4-(2,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
  参考文献：
  名称：

  Synthesis of dihydropyrimidinones via Biginelli multi-component reaction

  摘要：

  Five percentage perchloric acid doped silica is successfully used as an efficient mild catalyst for the synthesis of 4-aryl dihydropyrimidine-2(1H)-ones. This method offers significant advantages such as efficiency and mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.134

文献信息

• Synthesis of dihydropyrimidinones via Biginelli multi-component reaction
  作者：Srinivasa Reddy Narahari、Buchi Reddy Reguri、Omprakash Gudaparthi、Mukkanti K.

  DOI：10.1016/j.tetlet.2011.12.134

  日期：2012.3

  Five percentage perchloric acid doped silica is successfully used as an efficient mild catalyst for the synthesis of 4-aryl dihydropyrimidine-2(1H)-ones. This method offers significant advantages such as efficiency and mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.