4-benzyloxy-2,6-pyridinedicarboxamide | 350697-54-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-benzyloxy-2,6-pyridinedicarboxamide
• 英文别名: 4-(Benzyloxy)pyridine-2,6-dicarboxamide；4-phenylmethoxypyridine-2,6-dicarboxamide
• CAS: 350697-54-0
• 化学式: C₁₄H₁₃N₃O₃
• 分子量: 271.276
• InChiKey: GLLMVKBMOKKJRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-benzyloxy-2,6-pyridinedicarboxamide 在 lead 、 10% Pb/C 、 氢气 、 溴 、 甲烷 、 三乙胺 、 potassium hydroxide 作用下， 生成 N-(6-乙酰氨基-4-氧代-1H-吡啶-2-基)乙酰胺
  参考文献：
  名称：

  Glassy dynamics of hydrogen-bonded heteroditopic molecules

  摘要：

  A self-complementary heteroditopic molecule composed of thymine and diamidopyridine end groups and a flexible aliphatic interconnecting chain has been synthesized. The glassy dynamics of this hydrogen-bonded supramolecule have been investigated by using dielectric and rheological measurements, in combination with infra-red spectroscopy and solid-state C-13 NMR experiments. Decoupling of main dielectric relaxation from viscosity has been found in the vicinity of the glass transition and the temperature dependence of viscosity appears to be stronger than that of dielectric relaxation. The unusual dynamic decoupling phenomenon is ascribed to the chemical/dynamic heterogeneity and formation of hydrogen bonds in the supramolecules. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2012.07.052
• 作为产物：
  描述：

  二苄基4-(苄氧基)-2,6-吡啶二羧酸酯 在 氨 作用下， 以 甲醇 为溶剂， 生成 4-benzyloxy-2,6-pyridinedicarboxamide
  参考文献：
  名称：

  Identification of Sequence-Selective Receptors for Peptides with a Carboxylic Acid Terminus

  摘要：

  A combinatorial library of "tweezer" receptors, which incorporate a diamidopyridine unit to provide a specific binding site for a CO2H group (see picture), can be screened to identify sequence-selective receptors for chosen peptide guests with a CO2H terminus.

  DOI：

  10.1002/(sici)1521-3773(19990712)38:13/14<1993::aid-anie1993>3.0.co;2-h

文献信息

• Identification of Sequence-Selective Receptors for Peptides with a Carboxylic Acid Terminus
  作者：Thilo Fessmann、Jeremy D. Kilburn

  DOI：10.1002/(sici)1521-3773(19990712)38:13/14<1993::aid-anie1993>3.0.co;2-h

  日期：1999.7.12

  A combinatorial library of "tweezer" receptors, which incorporate a diamidopyridine unit to provide a specific binding site for a CO2H group (see picture), can be screened to identify sequence-selective receptors for chosen peptide guests with a CO2H terminus.
• Identification of Sequence Selective Receptors for Peptides with a Carboxylic Acid Terminus
  作者：Tobias Braxmeier、Mariangela Demarcus、Thilo Fessmann、Stephen McAteer、Jeremy D. Kilburn

  DOI：10.1002/1521-3765(20010504)7:9<1889::aid-chem1889>3.0.co;2-7

  日期：2001.5.4

  Split-and-mix libraries of resin-bound "tweezer" receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO2H group, leading to strong and selective receptors for peptide guests with a CO2H terminus. The role of the dye-label, attached to the peptide guest to allow visualisation of selective recognition events in the screening experiments, has also been examined and was found to have a significant influence on the binding selectivities.
• Proteomorphous Objects from Abiotic Backbones
  作者：Nicolas Delsuc、Jean-Michel Léger、Stéphane Massip、Ivan Huc

  DOI：10.1002/anie.200603390

  日期：2007.1
• Glassy dynamics of hydrogen-bonded heteroditopic molecules
  作者：Nan Lou、YangYang Wang、Haixia Li、Alexei P. Sokolov、Huiming Xiong

  DOI：10.1016/j.polymer.2012.07.052

  日期：2012.9

  A self-complementary heteroditopic molecule composed of thymine and diamidopyridine end groups and a flexible aliphatic interconnecting chain has been synthesized. The glassy dynamics of this hydrogen-bonded supramolecule have been investigated by using dielectric and rheological measurements, in combination with infra-red spectroscopy and solid-state C-13 NMR experiments. Decoupling of main dielectric relaxation from viscosity has been found in the vicinity of the glass transition and the temperature dependence of viscosity appears to be stronger than that of dielectric relaxation. The unusual dynamic decoupling phenomenon is ascribed to the chemical/dynamic heterogeneity and formation of hydrogen bonds in the supramolecules. (C) 2012 Elsevier Ltd. All rights reserved.