(3-Hydroxy-2-octadec-9-enoxypropyl) hexadecanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (3-Hydroxy-2-octadec-9-enoxypropyl) hexadecanoate
• 英文别名: (3-hydroxy-2-octadec-9-enoxypropyl) hexadecanoate
• 化学式: C₃₇H₇₂O₄
• 分子量: 581.0
• InChiKey: BQDHJDSEEVFZSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.6
• 重原子数：
  41
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• COMPOSITIONS FOR LIPASE ACTIVITY DETERMINATION AND METHOD OF DETERMINING ACTIVITY
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1813680A1

  公开（公告）日：2007-08-01

  [PROBLEMS] To provide lipase activity determination reagents which function by an enzymatic method. The reagents are easy to use in an ordinary clinical examination, have excellent handleability, and are excellent in accuracy and reproducibility. [MEANS FOR SOLVING PROBLEMS] Lipase activity is determined with any of reagents which comprise a low-concentration buffer and a diglyceride dissolved therein. The diglyceride is used as a substrate for lipase, whereby the liquid reagents can have long-term storage stability. One of the reagents converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, pyruvate kinase, lactate dehydrogenase, reduced NAD, ATP, and phosphoenol pyruvate. Another reagent converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, glucose, ADP-dependent hexokinase, glucose-6-phosphate dehydrogenase, oxidized NAD or oxidized NADP, and ATP. A further reagent converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, glycerol-3-phosphate oxidase, peroxidase, and a dye which colors in the presence of hydrogenperoxide.

  [问题] 提供用酶法测定脂肪酶活性的试剂。这些试剂易于在普通临床检查中使用，具有极好的可操作性，而且准确性和再现性极佳。 [解决问题的方法]脂肪酶活性的测定可使用由低浓度缓冲液和溶于其中的二甘油酯组成的试剂。二甘油酯用作脂肪酶的底物，因此液体试剂具有长期储存稳定性。其中一种试剂借助单甘油酯脂肪酶将脂肪酶反应产生的单甘油酯转化为甘油，并进一步含有甘油激酶、丙酮酸激酶、乳酸脱氢酶、还原型 NAD、ATP 和磷酸烯醇丙酮酸。另一种试剂在单甘油酯脂肪酶的帮助下将脂肪酶反应产生的单甘油酯转化为甘油，并进一步含有甘油激酶、葡萄糖、ADP 依赖性己糖激酶、葡萄糖-6-磷酸脱氢酶、氧化的 NAD 或氧化的 NADP 和 ATP。另一种试剂在单甘油酯脂肪酶的帮助下，将脂肪酶反应产生的单甘油酯转化为甘油，并进一步含有甘油激酶、甘油-3-磷酸氧化酶、过氧化物酶和一种在过氧化氢存在下着色的染料。
• METHOD FOR MEASURING ACTIVITY OF HUMAN PANCREATIC LIPASE
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP2987867A1

  公开（公告）日：2016-02-24

  A measurement method for human pancreatic lipase activity in a sample, includes a contact step of bringing a bile acid that makes a pH for giving a maximum value of human pancreatic lipase activity to be lower than 7.7, a diglyceride and a colipase into contact with the sample at pH 7.4 or lower; and a detection step of detecting a signal amount varying in accordance with the human pancreatic lipase activity in the sample, and the bile acid is a bile acid containing: one of or two or more of a-type bile acids selected from the group consisting of GDCA, GCDCA, TDCA, TCDCA and salts thereof; and/or a combination of one of or two or more of b-1-type bile acids selected from the group consisting of GCA, GUDCA, TCA, TUDCA and salts thereof, and one of or two or more of b-2-type bile acids selected from the group consisting of DCA, CDCA and salts thereof.

  一种样品中人胰脂肪酶活性的测量方法，包括以下接触步骤：将使人胰脂肪酶活性最大值的 pH 值低于 7.7 的胆汁酸、二甘油酯和胶质酶与 pH 值为 7.检测步骤是检测随样品中人胰脂肪酶活性变化而变化的信号量，胆汁酸是一种胆汁酸，其中含有选自 GDCA、GCDCA、TDCA、TCDCA 及其盐类的 a 型胆汁酸中的一种或两种以上；和/或选自 GCA、GUDCA、TCA、TUDCA 及其盐类的 b-1 型胆汁酸中的一种或两种以上，以及选自 DCA、CDCA 及其盐类的 b-2 型胆汁酸中的一种或两种以上的组合。
• Measurement method for human pancreatic lipase activity
  申请人：ASAHI KASEI PHARMA CORPORATION

  公开号：US10000791B2

  公开（公告）日：2018-06-19

  A measurement method for human pancreatic lipase activity in a sample, includes bringing a bile acid that makes a pH for giving a maximum value of human pancreatic lipase activity to be lower than 7.7, a diglyceride and a colipase into contact with the sample at pH 7.4 or lower; and detecting a signal amount varying in accordance with the human pancreatic lipase activity in the sample, and the bile acid is a bile acid containing: one of or two or more of a-type bile acids selected from the group consisting of GDCA, GCDCA, TDCA, TCDCA and salts thereof; and/or a combination of one of or two or more of b-1-type bile acids selected from the group consisting of GCA, GUDCA, TCA, TUDCA and salts thereof, and one of or two or more of b-2-type bile acids selected from the group consisting of DCA, CDCA and salts thereof.

  一种样品中人胰脂肪酶活性的测量方法，包括将使人胰脂肪酶活性最大值的 pH 值低于 7.7 的胆汁酸、二甘油酯和胶质酶与 pH 值为 7.4或更低的pH值与样品接触；并检测随样品中人胰脂肪酶活性变化而变化的信号量，胆汁酸是一种胆汁酸，其中含有选自 GDCA、GCDCA、TDCA、TCDCA 及其盐类的 a 型胆汁酸中的一种或两种以上；和/或选自 GCA、GUDCA、TCA、TUDCA 及其盐类的 b-1 型胆汁酸中的一种或两种以上，以及选自 DCA、CDCA 及其盐类的 b-2 型胆汁酸中的一种或两种以上的组合。
• Composition for Lipase Activity Determination and Method of Determing Activity
  申请人：Imamura Shigeyuki

  公开号：US20080038765A1

  公开（公告）日：2008-02-14

  [PROBLEMS] To provide lipase activity determination reagents which function by an enzymatic method. The reagents are easy to use in an ordinary clinical examination, have excellent handleability, and are excellent in accuracy and reproducibility. [MEANS FOR SOLVING PROBLEMS] Lipase activity is determined with any of reagents which comprise a low-concentration buffer and a diglyceride dissolved therein. The diglyceride is used as a substrate for lipase, whereby the liquid reagents can have long-term storage stability. One of the reagents converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, pyruvate kinase, lactate dehydrogenase, reduced NAD, ATP, and phosphoenol pyruvate. Another reagent converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, glucose, ADP-dependent hexokinase, glucose-6-phosphate dehydrogenase, oxidized NAD or oxidized NADP, and ATP. A further reagent converts a monoglyceride yielded by a lipase reaction into glycerol with the aid of monoglyceride lipase, and further contains glycerol kinase, glycerol-3-phosphate oxidase, peroxidase, and a dye which colors in the presence of hydrogen peroxide.
• MEASUREMENT METHOD FOR HUMAN PANCREATIC LIPASE ACTIVITY
  申请人：ASAHI KASEI PHARMA CORPORATION

  公开号：US20160024553A1

  公开（公告）日：2016-01-28

  A measurement method for human pancreatic lipase activity in a sample, includes a contact step of bringing a bile acid that makes a pH for giving a maximum value of human pancreatic lipase activity to be lower than 7.7, a diglyceride and a colipase into contact with the sample at pH 7.4 or lower; and a detection step of detecting a signal amount varying in accordance with the human pancreatic lipase activity in the sample, and the bile acid is a bile acid containing: one of or two or more of a-type bile acids selected from the group consisting of GDCA, GCDCA, TDCA, TCDCA and salts thereof; and/or a combination of one of or two or more of b-1-type bile acids selected from the group consisting of GCA, GUDCA, TCA, TUDCA and salts thereof, and one of or two or more of b-2-type bile acids selected from the group consisting of DCA, CDCA and salts thereof.