2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide | 577784-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-[5-(5-chloro-3-methyl-1-benzothiophen-2-yl)-2-methylpyrazol-3-yl]benzenesulfonamide
• CAS: 577784-91-9
• 化学式: C₁₉H₁₅Cl₂N₃O₂S₂
• 分子量: 452.4
• InChiKey: BVBDTTLISMIOJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITION FOR TRANSFERRING GENE TO CELL
  申请人：Ishihara Sangyo Kaisha, Ltd.

  公开号：EP3020809A1

  公开（公告）日：2016-05-18

  Disclosed are a composition for gene transfer, a method for introducing a gene into cell of a non-human animal, a method for introducing a gene into an in vitro cell, and a kit for gene transfer. The composition comprises (A) at least one lipid selected from the group consisting of sorbitan sesquioleate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan trioleate, sorbitan monooleate, L-α-phosphatidylinositol, L-α-dioleoyl phosphatidylethanolamine, octadecylamine, hexadecylamine, DOTAP, and cardiolipin; (B) at least one protein selected from the group consisting of albumin, casein, gelatin, and sericin; and (C) at least one positively charged substance selected from the group consisting of protamine sulfate, polyarginine, polylysine, polyethyleneimine, and hexadimethrine bromide.

  本发明公开了一种基因转移组合物、一种将基因导入非人类动物细胞的方法、一种将基因导入体外细胞的方法和一种基因转移试剂盒。组合物包括 (A) 至少一种选自山梨糖醇倍半油酸酯、山梨糖醇单月桂酸酯、山梨糖醇单棕榈酸酯、山梨糖醇单硬脂酸酯、山梨糖醇三油酸酯、山梨糖醇单油酸酯、L-α-磷脂酰肌醇、L-α-二油酰磷脂酰乙醇胺、十八胺、十六胺、DOTAP 和心磷脂的脂质；(B) 至少一种蛋白质，选自由白蛋白、酪蛋白、明胶和丝胶蛋白组成的组；以及 (C) 至少一种带正电荷的物质，选自由硫酸原胺、聚精氨酸、聚赖氨酸、聚乙烯亚胺和溴化六甲亚胺组成的组。
• Methods and compositions for gene-specific demethylation by DNA methyltransferase (DNMT)-RNA interaction
  申请人：Di Ruscio Annalisa

  公开号：US10941399B2

  公开（公告）日：2021-03-09

  The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.

  本发明涉及单链寡核苷酸嵌合 RNA 寡核苷酸。这些化合物能够靶向特定基因，降低 DNA 甲基转移酶的活性。因此，这些化合物特别适用于治疗与DNA甲基转移酶活性异常有关的疾病，如癌症或遗传性疾病。
• CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF
  申请人：Di Ruscio Annalisa

  公开号：US20140171492A1

  公开（公告）日：2014-06-19

  The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.
• [EN] CHIMERIC RNA OLIGONUCLEOTIDES AND USES THEREOF<br/>[FR] OLIGONUCLÉOTIDES D'ARN CHIMÉRIQUES ET LEURS UTILISATIONS
  申请人：BETH ISRAEL HOSPITAL

  公开号：WO2012142480A1

  公开（公告）日：2012-10-18

  The present invention relates to chimeric RNA oligonucleotides that are single-stranded oligonucleotides. These compounds are capable of targeting particular genes and reducing DNA methyltransferase activity. Accordingly, these compounds are particularly useful in the treatment of disease associated with aberrant DNA methyltransferase activity, such as cancer or a genetic disorder.