6-甲氧基己腈 | 137936-43-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 6-甲氧基己腈
• 英文名称: 6-methoxyhexanenitrile
• 英文别名: 6-Methoxy-hexannitril；6-Methoxy-capronitril；ε-Methoxy-n-capronsaeurenitril
• CAS: 137936-43-7
• 化学式: C₇H₁₃NO
• 分子量: 127.186
• InChiKey: JUYLTNNLOWYDEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-甲氧基己腈 在 水 、 硝酸 、 vanadia 作用下， 生成 5-氰基戊酸
  参考文献：
  名称：

  DE951984

  摘要：

  公开号：
• 作为产物：
  描述：

  1-溴-5-甲氧基戊烷 在 甲醇 、 potassium cyanide 作用下， 生成 6-甲氧基己腈
  参考文献：
  名称：

  Clarke, Journal of the Chemical Society, 1913, vol. 103, p. 1699

  摘要：

  DOI：

文献信息

• Reductive Beckmann fragmentation of α-alkoxycycloalkanone oxime acetates
  作者：Hiromichi Fujioka、Hideaki Yamamoto、Makoto Miyazaki、Takeshi Yamanaka、Kazuhiro Takuma、Yasuyuki Kita

  DOI：10.1016/s0040-4039(00)92387-6

  日期：1991.9

  The title reaction was achieved with Et3SiH in the presence of a catalytic amount of CF3SO3SiMe3. The reaction was applied to the synthesis of (±)-exo-brevicomine.

  在催化量的CF 3 SO 3 SiMe 3存在下，用Et 3 SiH完成标题反应。将反应物施加到的合成（±） -外型-brevicomine。
• Process for removal of carbon oxides from gas mixtures
  申请人：MONSANTO COMPANY

  公开号：EP0100764A1

  公开（公告）日：1984-02-15

  A process for simultaneous separation of carbon monoxide and carbon dioxide from a mixed gas stream comprising contacting the gas stream with a liquid nitrile absorbent having the general formula R-CN wherein R is selected from alkyl radicals having from one to five carbon atoms and alkoxyalkyl radicals having from two to ten carbon atoms, maintaining the temperature of the gas stream during separation at a temperature below the decomposition temperature of the nitrile absorbent and removing the nitrile absorbent, carbon monoxide and carbon dioxide mixture from contact with the mixed gas stream.

  一种从混合气体流中同时分离一氧化碳和二氧化碳的工艺，包括将气体流与具有通式 R-CN 的液态腈吸收剂接触，其中 R 选自具有 1 至 5 个碳原子的烷基和具有 2 至 10 个碳原子的烷氧基烷基；在分离过程中将气体流的温度保持在低于腈吸收剂分解温度的温度；将腈吸收剂、一氧化碳和二氧化碳混合物从与混合气体流的接触中移除。
• Harrower, Journal of the Chemical Society, 1931, p. 2054
  作者：Harrower

  DOI：——

  日期：——
• A Potent Isoprenylcysteine Carboxylmethyltransferase (ICMT) Inhibitor Improves Survival in Ras-Driven Acute Myeloid Leukemia
  作者：Nagore I. Marín-Ramos、Moisés Balabasquer、Francisco J. Ortega-Nogales、Iván R. Torrecillas、Ana Gil-Ordóñez、Beatriz Marcos-Ramiro、Pedro Aguilar-Garrido、Ian Cushman、Antonio Romero、Francisco J. Medrano、Consuelo Gajate、Faustino Mollinedo、Mark R. Philips、Mercedes Campillo、Miguel Gallardo、Mar Martín-Fontecha、María L. López-Rodríguez、Silvia Ortega-Gutiérrez

  DOI：10.1021/acs.jmedchem.9b00145

  日期：2019.7.11

  Blockade of Ras activity by inhibiting its post-translational methylation catalyzed by isoprenylcysteine carboxylmethyltransferase (ICMT) has been suggested as a promising antitumor strategy. However, the paucity of inhibitors has precluded the clinical validation of this approach. In this work we report a potent ICMT inhibitor, compound 3 [UCM-1336, IC50 = 2 mu M], which is selective against the other enzymes involved in the post-translational modifications of Ras. Compound 3 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia. Because ICMT inhibition impairs the activity of the four Ras isoforms regardless of its activating mutation, compound 3 surmounts many of the common limitations of available Ras inhibitors described so far. In addition, these results validate ICMT as a valuable target for the treatment of Ras-driven tumors.
• Palomaa, Chemische Berichte, 1941, vol. 74, p. 297
  作者：Palomaa

  DOI：——

  日期：——