(R)-2-benzylsulfanylmethyl-2-methyl-4-phenyl-oxazolidine | 950672-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-2-benzylsulfanylmethyl-2-methyl-4-phenyl-oxazolidine
• 英文别名: (4R)-2-(benzylsulfanylmethyl)-2-methyl-4-phenyl-1,3-oxazolidine
• CAS: 950672-60-3
• 化学式: C₁₈H₂₁NOS
• 分子量: 299.437
• InChiKey: QJQWACHPCNJIFW-ZENAZSQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-2-benzylsulfanylmethyl-2-methyl-4-phenyl-oxazolidine 在 盐酸 、 lithium hydride 、 magnesium bromide ethyl etherate 作用下， 以 四氢呋喃 、 二氯甲烷 、 甲苯 为溶剂， 反应 78.92h， 生成 (3R,5R)-methyl 3-(benzylthio-methyl)-3-methyl-2-oxo-5-phenylmorpholine-4-carboxylate
  参考文献：
  名称：

  Stereoselective synthesis of a dialkylhydantoin featuring an asymmetric Strecker reaction on an acyclic dialkyl ketone

  摘要：

  A diastereoselective Strecker reaction using (R)-(-)-phenylglycinol forms the basis of a concise scalemic route to dialkylhydantoin 1. The phenylglycinol functionality was exploited in the manipulation of the aminonitrile Strecker product through to the dialkylhydantoin via a short, efficient sequence involving crystalline intermediates. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.02.008

文献信息

• Novel Crystal Modifications
  申请人：Briggner Lars-Erik

  公开号：US20090221640A1

  公开（公告）日：2009-09-03

  Novel crystal modifications of (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione are disclosed together with processes for preparing such modifications, pharmaceutical compositions comprising such a modification, and the use of such a modification in therapy.

  本发明公开了(5S)-5-[4-(5-氯吡啶-2-氧基)-哌啶-1-磺酰甲基]-5-甲基咪唑烷-2,4-二酮的新颖晶体修饰，以及制备该修饰的过程、包含该修饰的药物组合物，以及在治疗中使用该修饰的方法。
• WO2007/106022
  申请人：——

  公开号：——

  公开（公告）日：——
• Stereoselective synthesis of a dialkylhydantoin featuring an asymmetric Strecker reaction on an acyclic dialkyl ketone
  作者：Neil Barnwell、Andrew Watts、Lindsay Purdie、Duncan M. Gill

  DOI：10.1016/j.tetlet.2012.02.008

  日期：2012.4

  A diastereoselective Strecker reaction using (R)-(-)-phenylglycinol forms the basis of a concise scalemic route to dialkylhydantoin 1. The phenylglycinol functionality was exploited in the manipulation of the aminonitrile Strecker product through to the dialkylhydantoin via a short, efficient sequence involving crystalline intermediates. (C) 2012 Elsevier Ltd. All rights reserved.