3-methoxy-4-nitro-biphenyl | 42271-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methoxy-4-nitro-biphenyl
• 英文别名: 2-methoxy-1-nitro-4-phenylbenzene
• CAS: 42271-42-1
• 化学式: C₁₃H₁₁NO₃
• 分子量: 229.235
• InChiKey: MMAGRHBUXJZMKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methoxy-4-nitro-biphenyl 在 镍 肼 作用下， 以 乙醇 为溶剂， 生成 3-methoxy-[1,1'-biphenyl]-4-amine
  参考文献：
  名称：

  Synthesis of some 3',2''-dioxamethylene-bridged p-quaterphenyls and related compounds

  摘要：

  DOI：

  10.1021/jo00965a016
• 作为产物：
  描述：

  硝基联苯 、 硫酸二甲酯 生成 3-methoxy-4-nitro-biphenyl
  参考文献：
  名称：

  Synthesis of some 3',2''-dioxamethylene-bridged p-quaterphenyls and related compounds

  摘要：

  DOI：

  10.1021/jo00965a016

文献信息

• PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
  申请人：Arora Nidhi

  公开号：US20120015962A1

  公开（公告）日：2012-01-19

  Compounds of the formula I or II: wherein X, m, Ar, R 1 and R 2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

  式I或II的化合物： 其中X，m，Ar，R1和R2如本文所定义。所述化合物对于治疗IRAK介导的疾病是有用的。
• Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators
  申请人：Hoffmann-La Roche Inc.

  公开号：US09255110B2

  公开（公告）日：2016-02-09

  Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

  式I或II的化合物： 其中X，m，Ar，R1和R2的定义如本文所述。该化合物对于治疗IRAK介导的疾病是有用的。
• PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3252054A1

  公开（公告）日：2017-12-06

  Compounds of the formula I or II: wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions.

  式 I 或 II 的化合物： 其中 X、m、Ar、R1 和 R2 如本文所定义。上述化合物可用于治疗 IRAK 介导的病症。
• Improved Suzuki-Miyaura Reactions of Aryldiazonium Salts with Boronic Acids by Tuning Palladium on Charcoal Catalyst Properties
  作者：François-Xavier Felpin、Eric Fouquet、Cécile Zakri

  DOI：10.1002/adsc.200800783

  日期：2009.3

  Abstractmagnified imageAn improved Suzuki–Miyaura cross‐coupling reaction of aryldiazonium tetrafluoroborates with boronic acids catalyzed by a highly active palladium catalyst supported on charcoal is described as an extremely practical and efficient protocol. A properties‐activity study of various catalysts clearly established that the optimal catalytic activity was obtained with palladium nanoparticles having a low oxidation degree and uniformly dispersed on the charcoal. The optimized reaction conditions allow the cross‐coupling to proceed at room temperature without any base and ligand in technical grade methanol. Although the catalyst could not be recycled, the low palladium contamination of the solvent and product after a simple filtration of the palladium on charcoal (Pd/C) renders the present protocol competitive and safer for the environment compared to more conventional homogeneous conditions. We have highlighted the efficiency of this novel protocol by a short synthesis of the fungicide Boscalid®.
• PYRAZOLO[1,5A]PYRIMIDINE AND THIENO[3,2B]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2593457B1

  公开（公告）日：2017-08-23