1-(1H-benzimidazol-2-yl)-2-[bis[2-(1H-benzimidazol-2-yl)-2-oxoethyl]amino]ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(1H-benzimidazol-2-yl)-2-[bis[2-(1H-benzimidazol-2-yl)-2-oxoethyl]amino]ethanone
• 化学式: C₂₇H₂₁N₇O₃
• 分子量: 491.5
• InChiKey: GYRNYDYAMLVVMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  141
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] METHOD FOR MULTIPLEXED DETECTION OF NUCLEIC ACIDS USING SPECTRALLY ENCODED BEADS<br/>[FR] MÉTHODES DE DÉTECTION MULTIPLEXE D'ACIDES NUCLÉIQUES AU MOYEN DE BILLES À CODAGE SPECTRAL
  申请人：CHAN ZUCKERBERG BIOHUB INC

  公开号：WO2020243200A1

  公开（公告）日：2020-12-03

  Methods for characterizing a population of microbes in a sample are described. The methods include: amplifying microbial polynucleotides obtained from the sample to form a plurality of amplicons and combining the amplicons with a plurality of microbeads, wherein each of the microbeads has a lanthanide spectral signature paired with the sequence of capture polynucleotides immobilized on the microbead. At least some of the capture polynucleotides comprise a sequence substantially complementary to a microbe-identifying sequence in one or more amplicons, such that at least some amplicons are captured onto beads by the capture polynucleotides and the microbe can be identified based on the lanthanide spectral signature of with which the capture polynucleotide is paired. Further described are methods for the identification of pathogens present in a sample by evaluating patterns of hybridization of a capture oligonucleotide to amplicons. Microbead compositions and methods for the preparation thereof are also described.