2-methyl-N-(4-methylphenyl)furan-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-N-(4-methylphenyl)furan-3-carboxamide
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.25
• InChiKey: UPIRDPVNNFUAOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methyl-N-(4-methylphenyl)furan-3-carboxamide 、 diphosphorus pentasulfide 以77%的产率得到
  参考文献：
  名称：

  FISER-JAKIC L.; KARAMAN B.; JAKOPCIC K., CROAT. CHEM. ACTA, 1980, 53, NO 1, 69-79

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-3-呋喃甲酰氯 、 乙烷,三氯氟- 生成 2-methyl-N-(4-methylphenyl)furan-3-carboxamide
  参考文献：
  名称：

  FISER-JAKIC L.; KARAMAN B.; JAKOPCIC K., CROAT. CHEM. ACTA, 1980, 53, NO 1, 69-79

  摘要：

  DOI：

文献信息

• NOVEL METHODS FOR TREATING NEURODEGENERATIVE DISEASES
  申请人：GENZYME CORPORATION

  公开号：US20160287549A1

  公开（公告）日：2016-10-06

  The invention relates to dihydroorate dehydrogenase (DHODH) inhibitors useful for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis.
• METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF HEARING LOSS
  申请人：St. Jude Children's Research Hospital

  公开号：US20180161340A1

  公开（公告）日：2018-06-14

  In one aspect, pharmaceutical compositions comprising a CDK2 inhibitor and one or more of at least one agent known to treat a hearing impairment and at least one agent known to prevent a hearing impairment, and methods of treating and/or preventing hearing impairments or disorders using the compositions are disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.