4-amino-1-[(2R,5R)-5-azido-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-amino-1-[(2R,5R)-5-azido-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• 化学式: C9H10F2N6O4
• 分子量: 304.21
• InChiKey: UXJYMPRXLVIVCK-KYVYOHOSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• AZIDO NUCLEOSIDES AND NUCLEOTIDE ANALOGS
  申请人：Beigelman Leonid

  公开号：US20120070415A1

  公开（公告）日：2012-03-22

  Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a nucleoside, a nucleotide and an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

  本文披露了核苷、核苷酸及其类似物，包括一个或多个核苷、核苷酸及其类似物的药物组合物，以及合成它们的方法。本文还披露了利用核苷、核苷酸和其类似物来改善和/或治疗疾病和/或状况的方法，包括来自副黏病毒和/或正黏病毒的感染。病毒感染的例子包括呼吸道合胞病毒（RSV）和流感感染。
• 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION
  申请人：Devos Rene Robert

  公开号：US20100003213A1

  公开（公告）日：2010-01-07

  The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
• 4'-Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
  申请人：Martin Joseph Armstrong

  公开号：US20100004192A1

  公开（公告）日：2010-01-07

  The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions containing such compounds.
• US6784166B2
  申请人：——

  公开号：US6784166B2

  公开（公告）日：2004-08-31
• US7608601B2
  申请人：——

  公开号：US7608601B2

  公开（公告）日：2009-10-27