1-isopropyl-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one | 25855-30-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-isopropyl-4-thioxo-3,4-dihydro-1H-pyrimidin-2-one
• 英文别名: 1-Propan-2-yl-4-sulfanylidenepyrimidin-2-one；1-propan-2-yl-4-sulfanylidenepyrimidin-2-one
• CAS: 25855-30-5
• 化学式: C₇H₁₀N₂OS
• 分子量: 170.235
• InChiKey: WNYXXBSKDGOEFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NUCLEOTIDE AND NUCLEOSIDE THERAPEUTICS COMPOSITIONS AND USES RELATED THERETO<br/>[FR] COMPOSITIONS THÉRAPEUTIQUES RENFERMANT DES NUCLÉOTIDES ET DES NUCLÉOSIDES ET UTILISATIONS ASSOCIÉES
  申请人：UNIV EMORY

  公开号：WO2016145142A1

  公开（公告）日：2016-09-15

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

  这份披露涉及到核苷酸和核苷类治疗组合物，用于治疗传染病、病毒感染和癌症，其中核苷酸或核苷的碱基至少含有一个硫醇、硫醌或硫醚。
• Substituted nucleotides and nucleosides for treating viral infections
  申请人：Emory University

  公开号：US11166973B2

  公开（公告）日：2021-11-09

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating viral infections, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether. The nucleotide or nucleoside is defined by Formula Ia below:

  本公开涉及治疗病毒感染的核苷酸和核苷治疗组合物和用途，其中核苷酸或核苷的碱基含有至少一种硫醇、硫酮或硫醚。核苷酸或核苷的定义如下式 Ia：
• Nucleotide and Nucleoside Therapeutic Compositions and Uses Related Thereto
  申请人：Emory University

  公开号：US20190298750A1

  公开（公告）日：2019-10-03

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.