6-羟基-2-苯基-嘧啶-4-羧酸 | 84659-98-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 6-羟基-2-苯基-嘧啶-4-羧酸
• 英文名称: 6-oxo-2-phenyl-1,6-dihydropyrimidine-4-carboxylic acid
• 英文别名: 6-Hydroxy-2-phenylpyrimidine-4-carboxylic acid；6-oxo-2-phenyl-1H-pyrimidine-4-carboxylic acid
• CAS: 84659-98-3
• 化学式: C₁₁H₈N₂O₃
• mdl: MFCD00856151
• 分子量: 216.196
• InChiKey: SNFPSSBYDIFPOX-UHFFFAOYSA-N

物化性质

• 溶解度：
  0.01 M

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  6-羟基-2-苯基-嘧啶-4-羧酸 生成 sodium;2-phenyl-6-(2H-tetrazol-5-ylcarbamoyl)pyrimidin-4-olate
  参考文献：
  名称：

  TEHRATI, TSUTOMU;OKU, TEHRUO;NAMIKI, TAKAYUKI;SIMADZAKI, NORIXIKO

  摘要：

  DOI：
• 作为产物：
  描述：

  6-oxo-2-phenyl-1H-pyrimidine-4-carbaldehyde 生成 6-羟基-2-苯基-嘧啶-4-羧酸
  参考文献：
  名称：

  TEHRATI, TSUTOMU;OKU, TEHRUO;NAMIKI, TAKAYUKI;SIMADZAKI, NORIXIKO

  摘要：

  DOI：

文献信息

• [EN] AMIDE DERIVATIVES AS SIRTUIN MODULATORS<br/>[FR] DÉRIVÉS D'AMIDE COMME MODULATEURS DE SIRTUINES
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2009058348A1

  公开（公告）日：2009-05-07

  Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

  提供的是由结构公式（I）表示的新的sirtuin调节化合物及其用途。sirtuin调节化合物可用于延长细胞寿命，以及治疗和/或预防多种疾病和紊乱，例如与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、凝血障碍、炎症、癌症和/或潮红相关的疾病或紊乱，以及将从增加线粒体活性中受益的疾病或紊乱。还提供了包含sirtuin调节化合物与另一种治疗剂的组合的药物组合物。
• [EN] PYRIMIDONE CARBOXAMIDE COMPOUNDS AS PDE2 INHIBITORS<br/>[FR] COMPOSÉS PYRIMIDONE CARBOXAMIDE UTILISÉS EN TANT QU'INHIBITEURS DE PDE2
  申请人：MERCK SHARP & DOHME

  公开号：WO2015096651A1

  公开（公告）日：2015-07-02

  Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.

  揭示了式（I）的嘧啶羧酰胺化合物，这些化合物可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病的治疗剂，以及其药物组合物和用途。
• HETEROCYCLIC COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20160264536A1

  公开（公告）日：2016-09-15

  The problem of the present invention is to provide a compound having a PDE2A inhibitory action, and useful as a prophylactic or therapeutic drug for schizophrenia, Alzheimer's disease and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

  本发明的问题是提供一种具有PDE2A抑制作用的化合物，可用作预防或治疗精神分裂症、阿尔茨海默病等疾病的药物。本发明涉及一种由式（I）表示的化合物：其中每个符号如在说明书中所述，或其盐。
• SOLUBILIZED THIAZOLOPYRIDINES
  申请人：Vu Chi B.

  公开号：US20110009381A1

  公开（公告）日：2011-01-13

  Provided herein are novel sirtuin-modulating compounds Structural Formula (I): and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了一种新的调节sirtuin的化合物结构式（I）和其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，治疗和/或预防各种疾病和疾病，包括与衰老或压力有关的疾病或疾病，糖尿病，肥胖症，神经退行性疾病，心血管疾病，血液凝块疾病，炎症，癌症和/或潮红，以及需要增加线粒体活性的疾病或疾病。还提供了包含sirtuin调节化合物与另一种治疗剂组合的组合物。
• AMIDE DERIVATIVES AS SIRTUIN MODULATORS
  申请人：Oalmann Christopher

  公开号：US20110039847A1

  公开（公告）日：2011-02-17

  Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了由结构式（I）所代表的新型sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于增加细胞寿命，并治疗和/或预防各种疾病和障碍，包括与衰老或压力有关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝固障碍、炎症、癌症和/或潮红症，以及需要增加线粒体活性的疾病或障碍。此外，还提供了含有sirtuin调节化合物与另一种治疗剂的组合物。