2-chloro-N-{[3,5-dichloro-4-(2-chloro-4-nitrophenoxy)phenyl]sulfonyl}ethanimidamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-{[3,5-dichloro-4-(2-chloro-4-nitrophenoxy)phenyl]sulfonyl}ethanimidamide
• 英文别名: N1-(2-Chloroethanimidoyl)-3,5-dichloro-4-(2-chloro-4-nitrophenoxy)benzene-1-sulfonamide；2-chloro-N'-[3,5-dichloro-4-(2-chloro-4-nitrophenoxy)phenyl]sulfonylethanimidamide
• 化学式: C₁₄H₉Cl₄N₃O₅S
• 分子量: 473.121
• InChiKey: YPBWSSSLBNNKJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  136
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Ubiquitin ligase inhibitors
  申请人：Ramesh V. Usha

  公开号：US20050009871A1

  公开（公告）日：2005-01-13

  This invention describes compounds useful as ubiquitin ligase inhibitors. The compounds of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also provides for pharmaceutical compositions comprising the compounds described in the invention for the treatment of conditions that require inhibition of ubiquitin ligases. Furthermore, the invention provides for methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound according to the invention.

  这项发明描述了作为泛素连接酶抑制剂有用的化合物。该发明的化合物可用作参与泛素化的生物体的生化途径的抑制剂。该发明还提供了包括该发明中描述的化合物的药物组合物，用于治疗需要抑制泛素连接酶的疾病。此外，该发明提供了一种抑制细胞中泛素化的方法，包括将欲抑制泛素化的细胞与该发明中的化合物接触。
• US7915293B2
  申请人：——

  公开号：US7915293B2

  公开（公告）日：2011-03-29
• [EN] UBIQUITIN LIGASE INHIBITORS<br/>[FR] INHIBITEURS DE LIGASE D'UBIQUITINE
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2005007621A2

  公开（公告）日：2005-01-27

  This invention describes compounds useful as ubiquitin ligase inhibitors. The compounds of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also provides for pharmaceutical compositions comprising the compounds described in the invention for the treatment of conditions that require inhibition of ubiquitin ligases. Furthermore, the invention provides for methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound according to the invention.