1-But-3-enyl-1H-benzotriazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 1-But-3-enyl-1H-benzotriazole
• 英文别名: 1-But-3-enylbenzotriazole
• 化学式: C₁₀H₁₁N₃
• 分子量: 173.217
• InChiKey: GQGHNIHXFCYKER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  T406石油添加剂 、 3-丁烯-1-醇 在 N-溴代丁二酰亚胺(NBS) 、 三苯基膦 作用下， 生成 1-But-3-enyl-1H-benzotriazole
  参考文献：
  名称：

  Mitsunobu 反应：1-（伯烷基）苯并三唑的替代合成

  摘要：

  摘要 1-（伯烷基）苯并三唑可以通过用三苯基膦、N-溴代琥珀酰亚胺和苯并三唑处理相应的醇以方便的收率获得。在这些条件下，醇只产生相应的 1-烷基-苯并三唑。烯丙醇和炔丙醇也以典型的 Sn2 方式进行区域特异性反应，并且没有发现源自质子重排的产物。

  DOI：

  10.1080/00397919708006100

文献信息

• Nicotinamide Derivatives
  申请人：Crawforth James Michael

  公开号：US20110306597A1

  公开（公告）日：2011-12-15

  The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are defined herein, to compositions containing such compounds and to the uses of such compounds for the treatment of allergic and respiratory conditions.

  本发明涉及公式(I)的化合物及其药学上可接受的盐和溶剂，其中取代基在此定义，以及包含这种化合物的组合物，以及这种化合物用于治疗过敏和呼吸系统疾病的用途。
• HUMAN MILK OLIGOSACCHARIDES TO PROMOTE GROWTH OF BENEFICIAL BACTERIA
  申请人：Abbott Laboratories

  公开号：US20140249103A1

  公开（公告）日：2014-09-04

  Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, and children for improving gastrointestinal function and tolerance, as well as the growth of beneficial bacteria. Additional suitable methods of using the nutritional compositions including the human milk oligosaccharides are also disclosed.
• METHODS FOR DECREASING THE INCIDENCE OF NECROTIZING ENTEROCOLITIS IN INFANTS, TODDLERS, OR CHILDREN USING HUMAN MILK OLIGOSACCHARIDES
  申请人：ABBOTT LABORATORIES

  公开号：US20170224714A1

  公开（公告）日：2017-08-10

  Disclosed are methods of reducing the incidence of necrotizing enterocolitis in an infant, toddler, or child using nutritional compositions including human milk oligosaccharides. The nutritional compositions including the human milk oligosaccharides are effective in reducing inflammation and the incidence of inflammatory diseases.
• The Mitsunobu Reaction: An Alternative Synthesis of 1-(Primary Alkyl)benzotriazoles
  作者：Alan R. Katritzky、Daniela C. Oniciu、Ion Ghiviriga

  DOI：10.1080/00397919708006100

  日期：1997.5

  by treating the corresponding alcohol with triphenylphosphine, N-bromosuccinimide and benzotriazole. Under these conditions, the alcohols gave exclusively the corresponding 1-alkyl-benzotriazoles. Allyl and propargyl alcohols also reacted regiospecifically in a typical Sn2 manner, and no products derived from prototropic rearrangement were found.

  摘要 1-（伯烷基）苯并三唑可以通过用三苯基膦、N-溴代琥珀酰亚胺和苯并三唑处理相应的醇以方便的收率获得。在这些条件下，醇只产生相应的 1-烷基-苯并三唑。烯丙醇和炔丙醇也以典型的 Sn2 方式进行区域特异性反应，并且没有发现源自质子重排的产物。