(4S)-2-[2-bis[4-(trifluoromethyl)phenyl]phosphorylphenyl]-5,5-diphenyl-4-propan-2-yl-4H-1,3-oxazole | 1255859-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4S)-2-[2-bis[4-(trifluoromethyl)phenyl]phosphorylphenyl]-5,5-diphenyl-4-propan-2-yl-4H-1,3-oxazole
• CAS: 1255859-79-0
• 化学式: C₃₈H₃₀F₆NO₂P
• 分子量: 677.626
• InChiKey: YYCRZDRWKLYHFZ-UMSFTDKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  48
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  (S)-2-(2-bromophenyl)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazole 、 bis(4-(trifluoromethyl)phenyl)phosphine oxide 在 caesium carbonate 、 N,N'-二甲基乙二胺 作用下， 以 甲苯 为溶剂， 以62%的产率得到(4S)-2-[2-bis[4-(trifluoromethyl)phenyl]phosphorylphenyl]-5,5-diphenyl-4-propan-2-yl-4H-1,3-oxazole
  参考文献：
  名称：

  Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides

  摘要：

  Herein an efficient and direct copper-catalyzed coupling of oxazoline-containing aryl bromides with electron-deficient secondary phosphine oxides is reported. The resulting tertiary phosphine oxides can be reduced to prepare a range of PHOX ligands. The presented strategy is a useful alternative to known methods for constructing PHOX derivatives. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.039

文献信息

• Rapid synthesis of an electron-deficient t-BuPHOX ligand: cross-coupling of aryl bromides with secondary phosphine oxides
  作者：Nolan T. McDougal、Jan Streuff、Herschel Mukherjee、Scott C. Virgil、Brian M. Stoltz

  DOI：10.1016/j.tetlet.2010.08.039

  日期：2010.10

  Herein an efficient and direct copper-catalyzed coupling of oxazoline-containing aryl bromides with electron-deficient secondary phosphine oxides is reported. The resulting tertiary phosphine oxides can be reduced to prepare a range of PHOX ligands. The presented strategy is a useful alternative to known methods for constructing PHOX derivatives. (C) 2010 Elsevier Ltd. All rights reserved.