1,1'-diethyl-5'-hydroxy-3-phenyl-1'H-spiro[pyrrole-2,6'-quinoline]-2',5(1H,5'H)-dione | 1520038-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,1'-diethyl-5'-hydroxy-3-phenyl-1'H-spiro[pyrrole-2,6'-quinoline]-2',5(1H,5'H)-dione
• 英文别名: 1,1'-diethyl-5-hydroxy-4'-phenylspiro[5H-quinoline-6,5'-pyrrole]-2,2'-dione
• CAS: 1520038-45-2
• 化学式: C₂₂H₂₂N₂O₃
• 分子量: 362.428
• InChiKey: RYPUIDKPXABCMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-ethyl-N-(1-ethyl-2-oxoquinolin-6-yl)-3-phenylprop-2-ynamide 在 iron(III) chloride 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以82%的产率得到1,1'-diethyl-5'-hydroxy-3-phenyl-1'H-spiro[pyrrole-2,6'-quinoline]-2',5(1H,5'H)-dione
  参考文献：
  名称：

  Iron(III) Chloride Catalyzed Synthesis of Functionalized Spiropyrimidines

  摘要：

  Potentially bioactive pyrimidine-annulated spiroheterocyclic compounds are synthesized in good to excellent yields using readily available, cheap and environmentally friendly iron(III) chloride (FeCl3) as the catalyst. The process is straightforward and provides a diverse range of spiropyrimidine derivatives via the 5-endo-dig mode of cyclization, starting from simple and easily available starting materials.

  DOI：

  10.1055/s-0033-1338533

文献信息

• Iron(III) Chloride Catalyzed Synthesis of Functionalized Spiropyrimidines
  作者：K. Majumdar、Sudipta Ponra、Tapas Ghosh

  DOI：10.1055/s-0033-1338533

  日期：——

  Potentially bioactive pyrimidine-annulated spiroheterocyclic compounds are synthesized in good to excellent yields using readily available, cheap and environmentally friendly iron(III) chloride (FeCl3) as the catalyst. The process is straightforward and provides a diverse range of spiropyrimidine derivatives via the 5-endo-dig mode of cyclization, starting from simple and easily available starting materials.