11-Oxa-4-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,3,5,7,9(17),13,15-heptaene-10,12-dione | 182241-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 11-Oxa-4-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,3,5,7,9(17),13,15-heptaene-10,12-dione
• CAS: 182241-45-8
• 化学式: C₁₅H₇NO₃
• 分子量: 249.225
• InChiKey: GVIQRJNOYMQUEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  11-Oxa-4-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,3,5,7,9(17),13,15-heptaene-10,12-dione 在 硫酸 、 硝酸 作用下， 生成 2-Nitro-5-oxa-10-aza-benzo[de]anthracene-4,6-dione
  参考文献：
  名称：

  The synthesis and antitumor evaluation of unsymmetrical bis-imides

  摘要：

  Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(96)00591-4
• 作为产物：
  描述：

  邻羧基苯乙酸 在 盐酸 、 氯化亚砜 、 碘 、 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 34.25h， 生成 11-Oxa-4-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,3,5,7,9(17),13,15-heptaene-10,12-dione
  参考文献：
  名称：

  A Practical Photochemical Synthesis of 6-AZA-1, 10-Phenanthroic Anhydride

  摘要：

  A high yield synthesis of 6-aza-1,10-phenanthroic anhydride has been developed. The key step is a volume-efficient photochemical cyclization of azastilbene 5 to the photochemically stable dihydroazaphenanthrene 9.

  DOI：

  10.1080/00397919608003778

文献信息

• US5416089A
  申请人：——

  公开号：US5416089A

  公开（公告）日：1995-05-16
• US5585382A
  申请人：——

  公开号：US5585382A

  公开（公告）日：1996-12-17
• [EN] BIS-IMIDE POLYCYCLIC AND HETEROCYCLIC CHROMOPHORES USEFUL AS TUMORICIDALS<br/>[FR] CHROMOPHORES BIS-IMIDE POLYCYCLIQUES ET HETEROCYCLIQUES UTILES COMME AGENTS ANTICANCEREUX
  申请人：THE DU PONT MERCK PHARMACEUTICAL COMPANY

  公开号：WO1995000490A1

  公开（公告）日：1995-01-05

  (EN) This invention relates to bis-imide derivatives of tri- and tetraamines of formula (I), pharmaceutical compositions containing them, and methods of using them to treat cancer, particularly solid tumors, in mammals.(FR) Cette invention concerne des dérivés bis-imide de triamines et de tétraamines de la formule (I), des compositions pharmaceutiques les contenant et des méthodes d'utilisation de celles-ci pour traiter le cancer, en particulier les tumeurs solides chez les mammifères.
• The synthesis and antitumor evaluation of unsymmetrical bis-imides
  作者：Robert J. Cherney、Stephen G. Swartz、Arthur D. Patten、Emeka Akamike、Jung-Hui Sun、Robert F. Kaltenbach、Steven P. Seitz、Carl H. Behrens、Zelleka Getahun、George L. Trainor、Mike Vavala、Mindy R. Kirshenbaum、Lisa M. Papp、Margaret P. Stafford、Philip M. Czerniak、Richard J. Diamond、Ronald J. McRipley、Roni J. Page、Janet L. Gross

  DOI：10.1016/s0960-894x(96)00591-4

  日期：1997.1

  Unsymmetrical bis-imides 1 were synthesized and evaluated as potential antitumor agents. These novel bis-imides were assessed using three criteria: in vitro cytotoxicity (L1210), in vitro DNA binding, and in vivo studies with human tumor xenografts in mice. These studies identified DMP 315 as a potent, water soluble antitumor agent. (C) 1997, Elsevier Science Ltd.
• A Practical Photochemical Synthesis of 6-AZA-1, 10-Phenanthroic Anhydride
  作者：M. E. Pierce、J. M. D. Fortunak、Q. Islam

  DOI：10.1080/00397919608003778

  日期：1996.10

  A high yield synthesis of 6-aza-1,10-phenanthroic anhydride has been developed. The key step is a volume-efficient photochemical cyclization of azastilbene 5 to the photochemically stable dihydroazaphenanthrene 9.