(+/-)-8-methyl-1,6,7,8-tetrahydrocyclopenta[b]pyrazolo[3,4-g]quinoxaline | 1256639-48-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (+/-)-8-methyl-1,6,7,8-tetrahydrocyclopenta[b]pyrazolo[3,4-g]quinoxaline
• 英文别名: 6-Methyl-2,8,12,13-tetrazatetracyclo[7.7.0.03,7.011,15]hexadeca-1(9),2,7,10,13,15-hexaene
• CAS: 1256639-48-1
• 化学式: C₁₃H₁₂N₄
• 分子量: 224.265
• InChiKey: YNNXKDXGMHHVRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基环戊烯醇酮 、 5,6-二氨基吲唑 在 溶剂黄146 作用下， 反应 0.5h， 生成 (+/-)-8-methyl-1,6,7,8-tetrahydrocyclopenta[b]pyrazolo[3,4-g]quinoxaline 、 (+/-)-6-methyl-1,6,7,8-tetrahydrocyclopenta[b]pyrazolo[3,4-g]quinoxaline
  参考文献：
  名称：

  Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives

  摘要：

  The synthesis of new pyrazolo[3,4-g]quinoxaline derivatives, as well as their Pim kinases (Pim-1, Pim-2, Pim-3) inhibitory potencies and in vitro antiproliferative activities toward a human fibroblast primary culture and three human solid cancer cell lines (PA1, PC3 and DU145) are described. The results obtained in this preliminary structure activity relationship study have pointed out that most of the compounds in this series exhibited interesting in vitro Pim-3 kinase inhibitory potencies. Moreover, some of the tested compounds have demonstrated favorable antiproliferative potencies. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.067

文献信息

• Synthesis and biological activities of pyrazolo[3,4-g]quinoxaline derivatives
  作者：Laurent Gavara、Emmanuelle Saugues、Georges Alves、Eric Debiton、Fabrice Anizon、Pascale Moreau

  DOI：10.1016/j.ejmech.2010.08.067

  日期：2010.11

  The synthesis of new pyrazolo[3,4-g]quinoxaline derivatives, as well as their Pim kinases (Pim-1, Pim-2, Pim-3) inhibitory potencies and in vitro antiproliferative activities toward a human fibroblast primary culture and three human solid cancer cell lines (PA1, PC3 and DU145) are described. The results obtained in this preliminary structure activity relationship study have pointed out that most of the compounds in this series exhibited interesting in vitro Pim-3 kinase inhibitory potencies. Moreover, some of the tested compounds have demonstrated favorable antiproliferative potencies. (C) 2010 Elsevier Masson SAS. All rights reserved.