Purine, 6-hydroxy, TMS

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Purine, 6-hydroxy, TMS
• 英文别名: trimethyl(7H-purin-6-yloxy)silane
• 化学式: C₈H₁₂N₄OSi
• 分子量: 208.295
• InChiKey: WDSAHFXJSONVER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,2-di-O-acetyl-5-O-benzoyl-3-C-cyano-3-O-mesyl-D-ribofuranose 、 Purine, 6-hydroxy, TMS 生成 9-(2'-O-acetyl-5'-O-benzoyl-3'-C-cyano-3'-O-mesyl-β-D-ribofuranosyl)hypoxanthine
  参考文献：
  名称：

  TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication

  摘要：

  TSAO derivatives represent a unique class of nucleosides that are specifically targeted at HIV-1 RT. This overview is focussed on the chemical synthesis, the conformational studies, the antiviral and metabolic properties of TSAO derivatives, as well as their mechanism of antiviral action and the molecular basis of the vapid selection of resistant HIV-1 strains that emerge in cell culture in the presence of TSAO derivatives.

  DOI：

  10.1080/15257779508012432

文献信息

• TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication
  作者：Maria Camarasa、Maria Péarez-Péarez、Sonsoles Velázquez、Ana San-Féalix、Rosa Alvarez、Simon Ingate、Maria Luisa Jimeno、Anna Karlsson、Erik De Clercq、Jan Balzarini

  DOI：10.1080/15257779508012432

  日期：1995.5.1

  TSAO derivatives represent a unique class of nucleosides that are specifically targeted at HIV-1 RT. This overview is focussed on the chemical synthesis, the conformational studies, the antiviral and metabolic properties of TSAO derivatives, as well as their mechanism of antiviral action and the molecular basis of the vapid selection of resistant HIV-1 strains that emerge in cell culture in the presence of TSAO derivatives.