1-N-(1-naphthalen-1-ylethyl)-3-phenylpropane-1,2-diamine | 1026647-17-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-N-(1-naphthalen-1-ylethyl)-3-phenylpropane-1,2-diamine
• CAS: 1026647-17-5
• 化学式: C₂₁H₂₄N₂
• 分子量: 304.435
• InChiKey: WMFOSFIRULFUNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-N-(1-naphthalen-1-ylethyl)-3-phenylpropane-1,2-diamine 、 2-氯苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-chloro-N-[1-(1-naphthalen-1-ylethylamino)-3-phenylpropan-2-yl]benzenesulfonamide
  参考文献：
  名称：

  N1-Arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor

  摘要：

  The synthesis and calcimimetic properties of N-1-arylsulfonyl-N-2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 mu M) produced 97+/-11% of the maximal stimulation of [H-3]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00382-6
• 作为产物：
  描述：

  N-(4-nitrobenzenesulfonyl)-2-benzylaziridine 在 potassium carbonate 、 苯硫酚 作用下， 以 二甲基亚砜 、 乙腈 为溶剂， 生成 1-N-(1-naphthalen-1-ylethyl)-3-phenylpropane-1,2-diamine
  参考文献：
  名称：

  N1-Arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor

  摘要：

  The synthesis and calcimimetic properties of N-1-arylsulfonyl-N-2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 mu M) produced 97+/-11% of the maximal stimulation of [H-3]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00382-6

文献信息

• N1-Arylsulfonyl-N2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines as novel calcimimetics acting on the calcium sensing receptor
  作者：Philippe Dauban、Sandrine Ferry、Hélène Faure、Martial Ruat、Robert H Dodd

  DOI：10.1016/s0960-894x(00)00382-6

  日期：2000.9

  The synthesis and calcimimetic properties of N-1-arylsulfonyl-N-2-(1-aryl)ethyl-3-phenylpropane-1,2-diamines are described. The most active compound of the series (3n, used at 10 mu M) produced 97+/-11% of the maximal stimulation of [H-3]IP production obtained by 10 mM Ca2+ in CHO cells expressing the calcium sensing receptor (CaSR). This calcimimetic activity was due to a specific interaction of this compound with the CaSR. (C) 2000 Elsevier Science Ltd. All rights reserved.