8-ethyl-3-methyl-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one | 1204429-26-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 8-ethyl-3-methyl-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one
• 英文别名: 8-Ethyl-3-methyl-2-phenylpyrido[1,2-a]pyrimidin-4-one
• CAS: 1204429-26-4
• 化学式: C₁₇H₁₆N₂O
• 分子量: 264.327
• InChiKey: ZMIZBQJMSYUCSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-氨基-4-乙基吡啶 、 2-甲基-3-氧代-3-苯基丙酸乙酯 在 polyphosphorus acid 作用下， 反应 1.0h， 生成 8-ethyl-3-methyl-2-phenyl-4H-pyrido[1,2-a]pyrimidin-4-one
  参考文献：
  名称：

  Identification of Pyrido[1,2-α]pyrimidine-4-ones as New Molecules Improving the Transcriptional Functions of Estrogen-Related Receptor α

  摘要：

  The nuclear estrogen-related receptor alpha (ERR alpha) plays a central role in the regulation of expression of the genes involved in mitochondrial biogenesis and oxidative metabolism. We have successfully identified a series of pyrido [1,2-alpha]pyrimidin-4-ones as new agonists enhancing the transcriptional functions of ERRa. The compounds potently elevated the m RNA levels and the protein levels of ERRa downstream targets. Consequently, the compounds improved the glucose and fatty acid uptake in C2C12 muscle cells.

  DOI：

  10.1021/jm200976s

文献信息

• COMPOUNDS OF ESTROGEN-RELATED RECEPTOR MODULATORS AND THE USES THEREOF
  申请人：Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences

  公开号：EP2314588A1

  公开（公告）日：2011-04-27

  The compounds according to formula (I), their pharmaceutically acceptable acid or base addition salts, and the uses thereof. These compounds and their pharmaceutically acceptable acid or base addition salts can be used for preparing medicaments for modulating estrogen related receptors (ERR), and treating metabolic diseases, such as high blood fat, fatty liver, hyperglycemia, diabetes, obesity. The substituents of the formula are defined in the description.

  根据式（I）的化合物、其药学上可接受的酸或碱加成盐及其用途。这些化合物及其药学上可接受的酸或碱加成盐可用于制备调节雌激素相关受体（ERR）和治疗代谢性疾病（如高血脂、脂肪肝、高血糖、糖尿病、肥胖症）的药物。式中取代基的定义见说明。
• 4H-Pyrido[1,2-a]pyrimidin-4-one derivatives as modulators of the estrogen-related receptors
  申请人：Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences

  公开号：EP2314588B1

  公开（公告）日：2014-11-05
• US8853221B2
  申请人：——

  公开号：US8853221B2

  公开（公告）日：2014-10-07
• Identification of Pyrido[1,2-α]pyrimidine-4-ones as New Molecules Improving the Transcriptional Functions of Estrogen-Related Receptor α
  作者：Lijie Peng、Xuefei Gao、Lei Duan、Xiaomei Ren、Donghai Wu、Ke Ding

  DOI：10.1021/jm200976s

  日期：2011.11.10

  The nuclear estrogen-related receptor alpha (ERR alpha) plays a central role in the regulation of expression of the genes involved in mitochondrial biogenesis and oxidative metabolism. We have successfully identified a series of pyrido [1,2-alpha]pyrimidin-4-ones as new agonists enhancing the transcriptional functions of ERRa. The compounds potently elevated the m RNA levels and the protein levels of ERRa downstream targets. Consequently, the compounds improved the glucose and fatty acid uptake in C2C12 muscle cells.