3-ethyl-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-ethyl-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one
• 英文别名: 3-ethyl-7H-[1,2,4]triazolo[4,3-a]pyrazin-8-one
• 化学式: C₇H₈N₄O
• 分子量: 164.16
• InChiKey: KOJIDNFVPJJWHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  59.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Cyclic dinucleotide
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US10980825B2

  公开（公告）日：2021-04-20

  The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

  本公开提供了一种具有 STING 激动活性的化合物，该化合物有望用作预防或治疗 STING 相关疾病的药物。 本公开涉及一种由式（I）表示的化合物： 其中各符号如描述中所定义，或其盐类。
• ANTIBODY-DRUG CONJUGATES COMPRISING A CYCLIC DINUCLEOTIDE
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20210106607A1

  公开（公告）日：2021-04-15

  The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.
• CYCLIC DINUCLEOTIDE
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20210137962A9

  公开（公告）日：2021-05-13

  The present disclosure provides a compound having a STING agonistic activity, which may be expected to be useful as an agent for the prophylaxis or treatment of STING-related diseases. The present disclosure relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.
• CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS
  申请人：ANDRESEN Brian M.

  公开号：US20210206796A1

  公开（公告）日：2021-07-08

  A class of polycyclic compounds of general formula (I), wherein Base 1 , Base 2 , Y, Z a , X a , X a1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a and R 9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
• Cyclic Di-Nucleotide Compounds as STING Agonists
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20220033431A1

  公开（公告）日：2022-02-03

  A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R 1 , R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. (I)