4-[1-[(2,3-difluorophenyl)methyl]benzotriazol-5-yl]-N-(2-methylpyrazol-3-yl)pyrimidin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并三唑类
• 英文名称: 4-[1-[(2,3-difluorophenyl)methyl]benzotriazol-5-yl]-N-(2-methylpyrazol-3-yl)pyrimidin-2-amine
• 化学式: C₂₁H₁₆F₂N₈
• 分子量: 418.4
• InChiKey: UOUKLFVLAVBJBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  86.3
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Serine/threonine kinase inhibitors
  申请人：Array BioPharma Inc.

  公开号：US10154995B2

  公开（公告）日：2018-12-18

  Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

  本发明提供了式 I 的化合物或其立体异构体、同系物或药学上可接受的盐，可用于治疗过度增殖、疼痛和炎症性疾病。本发明还公开了使用式 I 化合物或其立体异构体、同系物或药学上可接受的盐进行体外、原位和体内诊断、预防或治疗哺乳动物细胞中的此类疾病或相关病理条件的方法。
• SERINE/THREONINE KINASE INHIBITORS
  申请人：Genentech, Inc.

  公开号：EP3089788B1

  公开（公告）日：2018-10-24
• US9763942B2
  申请人：——

  公开号：US9763942B2

  公开（公告）日：2017-09-19
• [EN] SERINE/THREONINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE SÉRINE/THRÉONINE KINASES
  申请人：GENENTECH INC

  公开号：WO2015103133A1

  公开（公告）日：2015-07-09

  Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.