[EN] NEPRILYSIN INHIBITORS<br/>[FR] INHIBITEURS DE LA NÉPRILYSINE
申请人:THERAVANCE BIOPHARMA R & D IP LLC
公开号:WO2015116786A1
公开(公告)日:2015-08-06
In one aspect, the invention relates to compounds having the formula (I): where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
In one aspect, the invention relates to compounds having the formula I:
where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
一方面,本发明涉及具有式 I 的化合物:
其中 R1-R6 如说明书中所定义,或其药学上可接受的盐。这些化合物具有肾酶抑制活性。在另一方面,本发明涉及包含这些化合物的药物组合物;使用这些化合物的方法;以及制备这些化合物的工艺和中间体。