7-ACCA杂质A | 68506-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 中文名称: 7-ACCA杂质A
• 英文名称: 3-Chloro-8-oxo-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 英文别名: 3-Chloro-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• CAS: 68506-27-4
• 化学式: C₁₅H₁₃ClN₂O₄S
• 分子量: 352.798
• InChiKey: FTSGHIBZZRDGGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  benzhydryl 3-chloro-7-phenylacetamido-3-cephem-4-carboxylate 在 iodotrimethylsilane*triphenylphosphine 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以27%的产率得到7-ACCA杂质A
  参考文献：
  名称：

  用碘三甲基-硅烷-三苯基膦轻松去除对甲氧基苄基和二苯甲酯

  摘要：

  摘要 使用碘三甲基硅烷 (TMSI)-三苯基膦 (TPP) 在二氯甲烷中在室温下将头孢菌素衍生物的二苯甲基 (DPM) 和对甲氧基苄基 (PMB) 酯转化为相应的羧酸。

  DOI：

  10.1080/00397919908085986

文献信息

• PATHOGEN DETECTION
  申请人：University of Notre Dame Du Lac

  公开号：US20160319322A1

  公开（公告）日：2016-11-03

  A device for detecting bacteria in a sample, comprising: a substrate having a surface; and a plurality of Fe(III)-bound or Fe(III)-binding siderophores specific to the bacteria and covalently attached to the surface; wherein the siderophores are selected from the group consisting of one or more natural siderophores, siderophores having one or more of the formulas described herein, or combination thereof. Methods of detection are also provided.
• REDUCTION-TRIGGERED ANTIBACTERIAL SIDEROMYCINS
  申请人：MILLER Marvin J

  公开号：US20160368878A1

  公开（公告）日：2016-12-22

  A compound is provided, comprising: an Fe(III)-binding or an Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; a drug; and an Fe(III) to Fe(II) reduction triggered linker bound to the drug and the linker or, if no linker is present, then bound to the drug and the siderophore. Compositions and methods including the compound are also provided.
• A Facile Removal of<i>P</i>-Methoxybenzyl and Diphenylmethyl Ester with Iodotrimethyl-Silane-Triphenylphosphine
  作者：Kyung Hoi Cha、Tae Won Kang、Dong Ock Cho、Hong-Woo Lee、Jaewook Shin、Kyung Yong Jin、Kyung-Wan Kim、Jung-Woo Kim、Chung-Il Hong

  DOI：10.1080/00397919908085986

  日期：1999.10

  Abstract Diphenylmethyl (DPM) and p-methoxybenzyl (PMB) ester of cephalosporin derivatives were converted to the corresponding carboxylic acid using iodotrimethylsilane (TMSI)-triphenylphosphine (TPP) in dichloromethane at room temperature in good yields.

  摘要 使用碘三甲基硅烷 (TMSI)-三苯基膦 (TPP) 在二氯甲烷中在室温下将头孢菌素衍生物的二苯甲基 (DPM) 和对甲氧基苄基 (PMB) 酯转化为相应的羧酸。