N-{1-[1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]ethyl}benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-{1-[1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]ethyl}benzamide
• 英文别名: N-[1-(1-prop-2-enylbenzimidazol-2-yl)ethyl]benzamide
• 化学式: C₁₉H₁₉N₃O
• 分子量: 305.4
• InChiKey: SKDCXCATBQHMRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compositions and methods for increasing proliferation of adult salivary stem cells
  申请人：Chen Che-Hong

  公开号：US10457659B2

  公开（公告）日：2019-10-29

  The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an individual undergoing radiotherapy for head and neck cancer.

  本公开提供了增加成体唾液干细胞增殖的方法。这些方法包括在体内、体外或体外使成人唾液干细胞与醛脱氢酶（ALDH）激动剂接触。增加成体唾液干细胞的增殖可用于增加接受头颈癌放疗的人的成体唾液干细胞数量。
• MODULATORS OF ALDEHYDE DEHYDROGENASE AND METHODS OF USE THEREOF
  申请人：The Board of Trustees of The Leland Stanford Junior University

  公开号：EP2349279A1

  公开（公告）日：2011-08-03
• Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof
  申请人：Mochly-Rosen Daria

  公开号：US20100113423A1

  公开（公告）日：2010-05-06

  The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (ALDH) enzymatic activity, as well as compositions and formulations comprising the compounds. The present disclosure provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition.
• Compositions and Methods for Increasing Proliferation of Adult Salivary Stem Cells
  申请人：Chen Che-Hong

  公开号：US20140323520A1

  公开（公告）日：2014-10-30

  The present disclosure provides methods of increasing proliferation of adult salivary stem cells. The methods include contacting adult salivary stem cells in vivo, in vitro, or ex vivo with an aldehyde dehydrogenase (ALDH) agonist. Increasing proliferation of adult salivary stem cells can be carried out to provide for an increase in the number of adult salivary stem cells in an indi vidual undergoing radiotherapy for head and neck cancer.
• US20140343045A1
  申请人：——

  公开号：US20140343045A1

  公开（公告）日：2014-11-20