4-diphenylacetylamino-benzoic acid | 23105-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-diphenylacetylamino-benzoic acid
• 英文别名: 4-[(2,2-diphenylacetyl)amino]benzoic Acid
• CAS: 23105-45-5
• 化学式: C₂₁H₁₇NO₃
• 分子量: 331.371
• InChiKey: LVEZEKXRACCOLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-diphenylacetylamino-benzoic acid 在 氯化亚砜 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲苯 为溶剂， 生成 4-(2,2-diphenylacetylamino)-N-[4-(4-methoxyphenyl)-tetrahydro-2H-pyran-4-ylmethyl]benzamide
  参考文献：
  名称：

  Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine

  摘要：

  Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acylation of various amines to yield the corresponding diamides. Reaction of [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine with chlorides of N-substituted p-aminobenzoic acids has led to formation of diamides.

  DOI：

  10.1134/s1070363215050096
• 作为产物：
  描述：

  ethyl 4-(2,2-diphenylacetamido)benzoate 在 sodium hydroxide 作用下， 以 ethanole 、 水 为溶剂， 反应 17.0h， 生成 4-diphenylacetylamino-benzoic acid
  参考文献：
  名称：

  Neuropeptide Y antagonists

  摘要：

  这种化合物是一种神经肽Y拮抗剂，对治疗进食障碍、心血管疾病和其他生理紊乱有效。

  公开号：

  US06407120B1

文献信息

• Amide derivatives useful as Neuropeptide Y (NPY) antagonists
  申请人：Pfizer Products Inc.

  公开号：EP1033366A2

  公开（公告）日：2000-09-06

  The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.

  该化合物 是一种神经肽 Y 拮抗剂，可有效治疗进食障碍、心血管疾病和其他生理紊乱。
• HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
  申请人：Wilks Angela

  公开号：US20100081661A1

  公开（公告）日：2010-04-01

  Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to combat with the current spectrum of antimicrobial agents. Screening methods for selecting inhibitors of microbial heme oxygenase.
• US6407120B1
  申请人：——

  公开号：US6407120B1

  公开（公告）日：2002-06-18
• Neuropeptide Y antagonists
  申请人：Pfizer Inc.

  公开号：US06407120B1

  公开（公告）日：2002-06-18

  The compound is a neuropeptide Y antagonist and is effective in treating feeding disorders, cardiovascular diseases and other physiological disorders.

  这种化合物是一种神经肽Y拮抗剂，对治疗进食障碍、心血管疾病和其他生理紊乱有效。
• Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine
  作者：A. A. Agekyan、G. G. Mkryan

  DOI：10.1134/s1070363215050096

  日期：2015.5

  Reaction of 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxyl chloride with anesthesin followed by hydrolysis of the formed ester has afforded 4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carbonylamino]benzoic acid. The acid chloride has been used for acylation of various amines to yield the corresponding diamides. Reaction of [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine with chlorides of N-substituted p-aminobenzoic acids has led to formation of diamides.