1,3-Dihydroxy-2-methylpropan-2-aminium 4-methyl-2-oxo-2H-chromen-7-yl phosphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 1,3-Dihydroxy-2-methylpropan-2-aminium 4-methyl-2-oxo-2H-chromen-7-yl phosphate
• 英文别名: (1,3-dihydroxy-2-methylpropan-2-yl)azanium;(4-methyl-2-oxochromen-7-yl) phosphate
• 化学式: C18H31N2O10P
• mdl: MFCD00044932
• 分子量: 466.4
• InChiKey: BFRZFPYLAVZIPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.13
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  235
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• DETECTION OF IMMUNOGLOBULIN LIGHT CHAIN RESTRICTION BY RNA IN SITU HYBRIDIZATION
  申请人：MA Xiao-Jun

  公开号：US20140178869A1

  公开（公告）日：2014-06-26

  The invention provides a method for detecting immunoglobulin light chain restriction and clonality in B cells by obtaining a sample of B cells from a subject; conducting a duplex in situ hybridization assay on the sample using (i) at least one probe set which is designed to specifically hybridize to immunoglobulin kappa chain constant region (IGKCR) RNA; and (ii) at least one probe set which is designed to specifically hybridize to immunoglobulin lambda chain constant region (IGLCR) RNA; detecting signal associated with hybridized IGKCR probe and signal associated with hybridized IGLCR probe in a population of B cells in the sample; and determining a pattern of signal associated with hybridized IGKCR probe and hybridized IGLCR probe within individual cells in the B cell population, wherein the pattern of signal within individual cells indicates the presence or absence of light chain restriction and clonality of the B cells.
• DIFFERENTIATION BETWEEN TRANSIENT AND PERSISTENT HIGH-RISK HPV INFECTION BY IN SITU HYBRIDIZATION
  申请人：Advanced Cell Diagnostics, Inc.

  公开号：US20140357509A1

  公开（公告）日：2014-12-04

  The invention relates to methods of categorizing a cervical tissue or cytology sample by performing an in situ hybridization assay using an antisense E6 or E7 probe on a cervical tissue sample, wherein the antisense E6 or E7 probe can simultaneously detect HPV DNA and HPV RNA; detecting the presence of HPV nucleic acid; and categorizing the cervical tissue sample based on HPV nucleic acid expression.
• DUPLEX CHROMOGENIC ASSAY FOR IN SITU DETECTION OF NUCLEIC ACIDS
  申请人：Advanced Cellular Diagnostics, Inc.

  公开号：US20150045251A1

  公开（公告）日：2015-02-12

  The disclosure provides methods of detecting two or more target nucleic acids. The methods can include the steps of contacting a sample with two or more label probes having distinct enzyme labels and targeting distinct nucleic acid targets, binding the two or more label probes to the target nucleic acids by hybridization; contacting the sample with a first substrate for the first enzyme of the first label probe; reacting the first substrate with the first enzyme, thereby producing a first detectable signal; contacting the sample with a second substrate for the second enzyme of the second label probe; reacting the second substrate with the second enzyme, thereby producing a second detectable signal; and detecting the first detectable signal and the second detectable signal, thereby detecting the first and second target nucleic acids in the sample.
• US6387650B1
  申请人：——

  公开号：US6387650B1

  公开（公告）日：2002-05-14
• US6472167B1
  申请人：——

  公开号：US6472167B1

  公开（公告）日：2002-10-29