4-Fluoro-3-methoxybenzenethiol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 4-Fluoro-3-methoxybenzenethiol
• 英文别名: 4-fluoro-3-methoxybenzenethiol
• 化学式: C₇H₇FOS
• 分子量: 158.2
• InChiKey: ZWFKLESVRIVMPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  10.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] HSD17B13 INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS ET UTILISATIONS DE CEUX-CI
  申请人：INIPHARM INC

  公开号：WO2021211974A1

  公开（公告）日：2021-10-21

  Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such as NAFLD or NASH, or drug induced liver injury (DILI).

  本发明涉及HSD17B13抑制剂及包含所述抑制剂的药物组合物。所述化合物和组合物可用于治疗肝病、代谢性疾病或心血管疾病，例如非酒精性脂肪肝病（NAFLD）或非酒精性脂肪肝炎（NASH），或药物诱导的肝损伤（DILI）。
• SUBSTITUTED 3-HETEROARYLOXY-1H-PYRAZOLES AND SALTS THEREOF AND THEIR USE AS HERBICIDAL ACTIVE SUBSTANCES
  申请人：BAYER CROPSCIENCE AKTIENGESELLSCHAFT

  公开号：US20200181117A1

  公开（公告）日：2020-06-11

  A substituted 3-heteroaryloxy-1H-pyrazole of the general formula (I) or salt thereof Substituted 3-heteroaryloxy-1H-pyrazoles of the general formula (I) are described, as is their use as herbicides, in particular for controlling broad-leaved weeds and/or weed grasses in crops of useful plants and/or as plant growth regulators for influencing the growth of crops of useful plants described. The present invention also relates to herbicidal and/or plant growth-regulating compositions comprising one or more compounds of the general formula (I).

  通用式（I）的取代3-杂环氧基-1H-吡唑或其盐已被描述。 通用式（I）的取代3-杂环氧基-1H-吡唑被描述， 以及它们作为除草剂的用途，特别是用于控制作物中的阔叶杂草和/或杂草草，以及作为植物生长调节剂，影响作物生长的用途。 本发明还涉及包含一个或多个通用式（I）化合物的除草剂和/或植物生长调节剂组合物。
• Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease
  申请人：Lycera Corporation

  公开号：US10364237B2

  公开（公告）日：2019-07-30

  The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.

  本发明提供了四氢喹啉磺酰胺化合物、四氢萘磺酸化合物和相关化合物、药物组合物、促进RORy活性的方法、增加受试者体内IL-17含量的方法，以及使用此类化合物治疗癌症和其他疾病的方法。
• TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE
  申请人：Lycera Corporation

  公开号：EP3140291A2

  公开（公告）日：2017-03-15
• TETRAHYDROQUINOLINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORy AND THE TREATMENT OF DISEASE
  申请人：Lycera Corporation

  公开号：US20170183331A1

  公开（公告）日：2017-06-29

  The invention provides tetrahydroquinoline sulfonamide compounds, tetrahydronaphthalene sulfonyl compounds, and related compounds, pharmaceutical compositions, methods of promoting RORy activity, methods of increasing the amount of IL-17 in a subject, and methods of treating cancer and other medical disorders using such compounds.