A tandem Heck–aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines
作者:Ke Chen、Sumod A. Pullarkat
DOI:10.1039/c2ob25854d
日期:——
A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.