(1-benzyl-6-oxo-1,6-dihydropyridazin-4-yl)methyl piperidin-1-ylcarbodithioate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (1-benzyl-6-oxo-1,6-dihydropyridazin-4-yl)methyl piperidin-1-ylcarbodithioate
• 英文别名: (1-Benzyl-6-oxopyridazin-4-yl)methyl piperidine-1-carbodithioate；(1-benzyl-6-oxopyridazin-4-yl)methyl piperidine-1-carbodithioate
• 化学式: C₁₈H₂₁N₃OS₂
• 分子量: 359.516
• InChiKey: WGIMDUWTRXRGFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  93.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Pyridazin-3(2H)-one derivatives as monoamine oxidase selective isoform B inhibitors
  申请人：UNIVERSIDADE DE VIGO

  公开号：US10253000B2

  公开（公告）日：2019-04-09

  The present invention refers to pyridazin-3(2H)-one derivatives of general structure I, II and III, which are selective MAO-B inhibitors, and to the use thereof for preparing medicaments intended to treat disorders derived from MAO-B hyperactivity, particularly degenerative disorders of the central nervous system (CNS), such as Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. These are pyridazin-3(2H)-one derivatives having dithiocarbamate moieties bonded to position 4, 5 or 6 through an alkyl chain of variable length (n=1, 2, 3). This invention is also directed to the preparation of said compounds.

  本发明涉及一般结构 I、II 和 III 的哒嗪-3(2H)-酮衍生物，它们是选择性 MAO-B 抑制剂，并涉及使用它们制备药物，以治疗 MAO-B 活性亢进引起的疾病，特别是中枢神经系统（CNS）的退行性疾病，如帕金森病（PD）、阿尔茨海默病（AD）和其他痴呆症。这些衍生物为哒嗪-3(2H)-酮衍生物，其第 4、5 或 6 位通过长度可变的烷基链（n=1、2、3）键合有二硫代氨基甲酸酯分子。本发明还涉及上述化合物的制备。
• PYRIDAZIN-3(2H)-ONE DERIVATIVES AS MONOAMINE OXIDASE SELECTIVE ISOFORM B INHIBITORS (As Amended)
  申请人：UNIVERSIDADE DE VIGO

  公开号：US20180215718A1

  公开（公告）日：2018-08-02

  The present invention refers to pyridazin-3(2H)-one derivatives of general structure I, II and III, which are selective MAO-B inhibitors, and to the use thereof for preparing medicaments intended to treat disorders derived from MAO-B hyperactivity, particularly degenerative disorders of the central nervous system (CNS), such as Parkinson's disease (PD), Alzheimer's disease (AD) and other dementias. These are pyridazin-3(2H)-one derivatives having dithiocarbamate moieties bonded to position 4, 5 or 6 through an alkyl chain of variable length (n=1, 2, 3). This invention is also directed to the preparation of said compounds.
• [EN] PYRIDAZIN-3(2H)-ONE DERIVATIVES WHICH ARE SELECTIVE INHIBITORS OF THE ISOFORM B OF MONOAMINE OXIDASE<br/>[ES] DERIVADOS DE PIRIDAZIN-3(2H)-ONA INHIBIDORES SELECTIVOS DE LA ISOFORMA B DE LA MONOAMINOOXIDASA<br/>[FR] DÉRIVÉS DE PYRIDAZINE-3(2H)-ONE, INHIBITEURS SÉLECTIFS DE L'ISOFORME B DE LA MONOAMINE OXYDASE
  申请人：UNIV VIGO

  公开号：WO2015132427A1

  公开（公告）日：2015-09-11

  Esta invención se refiere a derivados de piridazin-3(2H)-ona de estructura general (I), (II) y (III), que son inhibidores selectivos de la MAO-B, y a su uso para preparar medicamentos destinados a tratar trastornos derivados de la hiperactividad de la MAO-B, en particular trastornos degenerativos del sistema nervioso central (SNC), como la enfermedad de Pakinson (EP), la enfermedad de Alzheimer (EA) y otras demencias. Se trata de derivados de piridazin-3(2H)-ona que presentan fragmentos de ditiocarbamato enlazados a la posición 4, 5 o 6 a través de una cadena alquílica de longitud variable (n=l, 2, 3). Esta invención también se dirige a la preparación de dichos compuestos.