4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(phenylmethylene)amino]-2-thioxo- | 1417353-16-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4(1H)-Pyrimidinone, 2,3-dihydro-5,6-bis[(phenylmethylene)amino]-2-thioxo-
• 英文别名: 5,6-bis(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one
• CAS: 1417353-16-2
• 化学式: C₁₈H₁₄N₄OS
• 分子量: 334.4
• InChiKey: NEEVCWPRIZJJRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] METHODS FOR MODULATING GENOME EDITING<br/>[FR] MÉTHODES POUR MODULER L'ÉDITION GÉNOMIQUE
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2016115326A1

  公开（公告）日：2016-07-21

  Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homologydirected repair (HDR) and/or nonhomologous end joining (NHEJ) repair of double-strand breaks in a target DNA sequence. Also provided herein are methods for preventing or treating a genetic disease in a subject by enhancing precise genome editing to correct a mutation in a target gene associated with the genetic disease. Further provided herein are systems and methods for screening small molecule libraries to identify novel modulators of genome editing. The present invention can be used with any cell type and at any gene locus that is amenable to nuclease-mediated genome editing technology.