(2-benzyloxy)biphenyl-2'-yl N-methyl-acetamide | 197841-18-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-benzyloxy)biphenyl-2'-yl N-methyl-acetamide
• 英文别名: N-methyl-2-[2-(2-phenylmethoxyphenyl)phenyl]acetamide
• CAS: 197841-18-2
• 化学式: C₂₂H₂₁NO₂
• 分子量: 331.414
• InChiKey: VTLCHHTXQMDLAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  草酰氯 、 (2-benzyloxy)biphenyl-2'-yl N-methyl-acetamide 以79%的产率得到dibenzo[b,d]oxepine-11-spiro-2'-N-methyl-oxazolidine-4,5-dione
  参考文献：
  名称：

  Sequential bicyclization of biphenyl acetamides promoted by (COCl)2/SnCl4. Total synthesis of 4,5-dioxoaporphines

  摘要：

  The reaction of biphenyl acetamides with excess of oxalyl chloride/stannyl chloride offers a one pot, high-yield entry to 4,5-dioxoaporphine alkaloids. This strategy has been applied to the synthesis of 4,5-dioxodehydrocorydine starting from 1-iodo-2,3-dimethoxybenzene. The cytotoxicity of tetraoxygenated 4,5-dioxoaporphines has been evaluated. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00923-x
• 作为产物：
  描述：

  (2'-benzyloxy)biphenyl-2-yl acetic acid 在 草酰氯 作用下， 以 吡啶 、 水 、 三乙胺 、 丙酮 、 苯 为溶剂， 反应 1.5h， 生成 (2-benzyloxy)biphenyl-2'-yl N-methyl-acetamide
  参考文献：
  名称：

  Sequential bicyclization of biphenyl acetamides promoted by (COCl)2/SnCl4. Total synthesis of 4,5-dioxoaporphines

  摘要：

  The reaction of biphenyl acetamides with excess of oxalyl chloride/stannyl chloride offers a one pot, high-yield entry to 4,5-dioxoaporphine alkaloids. This strategy has been applied to the synthesis of 4,5-dioxodehydrocorydine starting from 1-iodo-2,3-dimethoxybenzene. The cytotoxicity of tetraoxygenated 4,5-dioxoaporphines has been evaluated. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00923-x