2-bromo-1-(1-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2-bromo-1-(1-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)ethanone
• 英文别名: 2-bromo-1-(5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-3-yl)ethanone
• 化学式: C₁₈H₁₈BrNO
• 分子量: 344.2
• InChiKey: OCAVIGFZAPRJPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• PYRAZOLYL PYRIMIDINONE COMPOUNDS AND THE USES THEREOF
  申请人：Purdue Research Foundation

  公开号：US20210100797A1

  公开（公告）日：2021-04-08

  The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

  本发明涉及一种使用嘧啶酮化合物类治疗慢性疼痛、阿片类药物依赖、酒精使用障碍或自闭症的方法，该化合物为腺苷酸环化酶1（AC1）抑制剂。本发明还涉及使用本文所述化合物的药物组合物和用于治疗哺乳动物疾病的方法。
• NOVEL SCAFFOLD OF ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE
  申请人：Purdue Research Foundation

  公开号：US20190023688A1

  公开（公告）日：2019-01-24

  The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

  本发明涉及一种治疗慢性疼痛、阿片类依赖、酒精使用障碍或自闭症的方法，使用一类嘧啶酮化合物，即腺苷酸环化酶1（AC1）抑制剂。本发明还涉及使用本文所披露的这些化合物治疗哺乳动物疾病的药物组合物和方法。
• ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE
  申请人：Purdue Research Foundation

  公开号：US20190002418A1

  公开（公告）日：2019-01-03

  This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.

  本申请公开了一系列选择性腺苷酸环化酶1（AC1）抑制剂作为疼痛治疗的药物。这些化合物可能提供一种有效的治疗慢性/炎性疼痛的方法。这些化合物还可以预防阿片类药物依赖和/或减少阿片类药物依赖。该发明涉及方法和组合物两个方面。
• Adenylyl cyclase inhibitors for chronic pain and opioid dependence
  申请人：Purdue Research Foundation

  公开号：US10457653B2

  公开（公告）日：2019-10-29

  This present application disclosed a series of selective adenylyl cyclase 1 (AC1) inhibitors, compounds having a formula or a pharmaceutically acceptable salt thereof, as a pain therapeutic. Those compounds may provide an effective method of treatment for chronic/inflammatory pain. Those compounds may also prevent opioid dependence and/or reduce opioid dependence. Both method and composition matters are within the scope of this invention.

  本申请公开了一系列选择性腺苷酸环化酶 1（AC1）抑制剂，这些化合物的化学式为 或其药学上可接受的盐，作为疼痛治疗剂。这些化合物可为慢性/炎症性疼痛提供有效的治疗方法。这些化合物还可以预防阿片类药物依赖和/或减少阿片类药物依赖。方法和组合物均属于本发明的范围。
• Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence
  申请人：Purdue Research Foundation

  公开号：US10662176B2

  公开（公告）日：2020-05-26

  The present invention relates to a method of treatment for chronic pain, opioid dependence, alcohol use disorder or autism using a class of pyrimidinone compounds, an adenylyl cyclase 1 (AC1) inhibitor. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases in mammals using those compounds disclosed herein.

  本发明涉及一种使用一类嘧啶酮化合物、腺苷酸环化酶1（AC1）抑制剂治疗慢性疼痛、阿片类药物依赖、酒精使用障碍或自闭症的方法。本文所述的发明还涉及使用本文公开的这些化合物治疗哺乳动物疾病的药物组合物和方法。