N-benzoyl-N'-butyl-guanidine | 91646-32-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoyl-N'-butyl-guanidine
• 英文别名: N-Benzoyl-N'-butyl-guanidin；N-benzoyl-N'-butylguanidine；N-(N'-butylcarbamimidoyl)benzamide
• CAS: 91646-32-1
• 化学式: C₁₂H₁₇N₃O
• 分子量: 219.286
• InChiKey: KHAVDGWUKZDWMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-benzoyl-N'-n-butylthiourea 在 ammonium hydroxide 、 sodium bismuthate 、 bismuth(III) iodide 、 三乙胺 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以62%的产率得到N-benzoyl-N'-butyl-guanidine
  参考文献：
  名称：

  Exploring the antileishmanial activity of N¹,N²-disubstituted-benzoylguanidines: synthesis and molecular modeling studies

  摘要：

  DOI：

  10.1080/07391102.2021.1959403

文献信息

• Risk-resistance adaptation model for caregivers and their children with sickle cell syndromes
  作者：Ronald T. Brown、Richard Lambert、Danielle Devine、Kevin Baldwin、Robert Casey、Karla Doepke、Carolyn E. Ievers、Lewis Hsu、Iris Buchanan、James Eckman

  DOI：10.1007/bf02895780

  日期：2000.6

  This investigation examined the risk-resistance adaptation model for children with sickle cell disease and their primary caregivers. Participants were 55 children, ranging in age from 5 to 16 years with a mean age of 9 years 2 months, diagnosed with sickle cell disease and their primary caregivers, recruited from a university medical center Measures included adjustment (i.e. primary caregiver and child adjustment), risk factors (i.e. disease and disability, functional independence, and psychosocial stressors), resistance factors (i.e, intrapersonal health locus of control, social-ecological), and stress processing (coping). Primary caregivers' adjustment was associated with developmental coping, R-change(2) = .08, and child adaptation was associated with an internal health locus of control, R-change(2) = .22. An indirect effect of primary caregivers' coping on child adjustment was found through influence on primary caregivers' adjustment, R-change(2) = .11. The findings support research among other chronically ill populations that suggests an association between coping and disease adjustment. The results were interpreted to support the use of theoretically driven models in predicting the adaptation of children with chronic illness and adjustment in their caregivers.
• Studies in the Pyrazole Series. VIII.¹ Aminolyses of Some 3,5-Dimethyl-1-acylguanylpyrazoles
  作者：F. L. SCOTT

  DOI：10.1021/jo01363a008

  日期：1957.12.1
• Exploring the antileishmanial activity of <i>N</i>¹,<i>N</i>²-disubstituted-benzoylguanidines: synthesis and molecular modeling studies
  作者：Kaio Maciel de Santiago-Silva、Bruna Taciane da Silva Bortoleti、Tiago de Oliveira Brito、Ivete Conchon Costa、Camilo Henrique da Silva Lima、Fernando Macedo、Milena Menegazzo Miranda-Sapla、Wander Rogério Pavanelli、Marcelle de Lima Ferreira Bispo

  DOI：10.1080/07391102.2021.1959403

  日期：2022.12.12