7-氯-N-甲基-4-氧代-N-苯基-1H-喹啉-3-甲酰胺 | 861675-57-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 7-氯-N-甲基-4-氧代-N-苯基-1H-喹啉-3-甲酰胺
• 英文名称: 7-Chloro-4-hydroxy-quinoline-3-carboxylic acid methyl-phenyl-amide
• 英文别名: 7-chloro-4-hydroxy-N-methyl-N-phenylquinoline-3-carboxamide；7-chloro-N-methyl-4-oxo-N-phenyl-1H-quinoline-3-carboxamide
• CAS: 861675-57-2
• 化学式: C₁₇H₁₃ClN₂O₂
• 分子量: 312.755
• InChiKey: HIJZTYXWNSFRDJ-UHFFFAOYSA-N

物化性质

• 沸点：
  519.6±50.0 °C(Predicted)
• 密度：
  1.392±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二乙基2-[[(3-氯苯基)氨基]亚甲基]丙二酸酯 以 二苯醚 为溶剂， 生成 7-氯-N-甲基-4-氧代-N-苯基-1H-喹啉-3-甲酰胺
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator

  摘要：

  A series of novel quinoline-3-carboxamide derivatives were synthesized and evaluated for their immunomodulatory activity. The compounds were tested in vitro for effects on spleen lymphocyte proliferation and TNF-alpha production by macrophage. Three compounds showed immunomodulatory profiles similar to and more potent than those of linomide and FR137316 and were selected for further pharmacological studies in vivo. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.040

文献信息

• Design, synthesis, and biological evaluation of novel 4-hydro-quinoline-3-carboxamide derivatives as an immunomodulator
  作者：Jun-Feng He、Liu-Hong Yun、Ri-Fang Yang、Zhi-Yong Xiao、Jun-Ping Cheng、Wen-Xia Zhou、Yong-Xiang Zhang

  DOI：10.1016/j.bmcl.2005.04.040

  日期：2005.6

  A series of novel quinoline-3-carboxamide derivatives were synthesized and evaluated for their immunomodulatory activity. The compounds were tested in vitro for effects on spleen lymphocyte proliferation and TNF-alpha production by macrophage. Three compounds showed immunomodulatory profiles similar to and more potent than those of linomide and FR137316 and were selected for further pharmacological studies in vivo. (c) 2005 Elsevier Ltd. All rights reserved.