palmitoyl-Gly-Val-Val-Val-Ala-Ala-Ala-Glu-Glu-Glu-OH | 1013921-26-0

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: palmitoyl-Gly-Val-Val-Val-Ala-Ala-Ala-Glu-Glu-Glu-OH
• 英文别名: (2S)-2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-(hexadecanoylamino)acetyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]butanoyl]amino]butanoyl]amino]pentanedioic acid
• CAS: 1013921-26-0
• 化学式: C₅₇H₉₈N₁₀O₁₈
• 分子量: 1211.46
• InChiKey: CDQWKEBHMGLZIO-RFSPLIETSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  85
• 可旋转键数：
  46
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  440
• 氢给体数：
  14
• 氢受体数：
  18

反应信息

• 作为产物：
  描述：

  (2S)-2-[[(2S)-4-carboxy-2-[[(2S)-4-carboxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[hexadecanoyl-[(2-nitrophenyl)methyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]butanoyl]amino]butanoyl]amino]pentanedioic acid 在 ammonium hydroxide 作用下， 生成 palmitoyl-Gly-Val-Val-Val-Ala-Ala-Ala-Glu-Glu-Glu-OH
  参考文献：
  名称：

  Quadruple Helix Formation of a Photoresponsive Peptide Amphiphile and Its Light-Triggered Dissociation into Single Fibers

  摘要：

  Using a peptide amphiphile having a bulky photolabile 2-nitrobenzyl group between the alkyl chain and the peptide segment, we demonstrated quadruple helical fiber formation and its dissociation into single fibrils in response to light. Putting the bulky group close to the core of a fibril is thought to induce a distortion of the alignment of molecules, which can in turn lead to quadruple helices. Photoirradiation to cleave the bulky group transforms the helices into single fibrils.

  DOI：

  10.1021/ja711213s