3-benzylphthalic acid | 1073323-59-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzylphthalic acid
• CAS: 1073323-59-7
• 化学式: C₁₅H₁₂O₄
• 分子量: 256.258
• InChiKey: KFALJTKYGZDSFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  一氧化碳 、 2-苄基苯甲酸 在 sodium acetate 、 palladium diacetate 、 silver carbonate 作用下， 以 1,4-二氧六环 为溶剂， 130.0 ℃ 、101.33 kPa 条件下， 反应 18.0h， 以91%的产率得到3-benzylphthalic acid
  参考文献：
  名称：

  通过 Pd(II)-催化芳基和乙烯基 C-H 键的羧化合成 1,2- 和 1,3-二羧酸

  摘要：

  已经开发了用于苯甲酸和苯乙酸衍生物直接羧化以形成二羧酸的 Pd(II) 催化反应方案。反应条件也适用于乙烯基 CH 键的羧化。来自羧酸的第一个 CH 插入 Pd-芳基配合物已通过 X 射线晶体学表征。

  DOI：

  10.1021/ja8063827

文献信息

• Stabilized Polymeric Delivery System
  申请人：Dadey Eric

  公开号：US20080299168A1

  公开（公告）日：2008-12-04

  The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.

  本发明涉及一种用于持续和可控地释放一组生物活性剂的递送系统。更具体地，本发明涉及一种递送系统和递送含有亲核官能团的生物活性剂的方法，该方法通过可生物降解的持续释放植入物进行。该植入物可以是预制植入物、微粒或原位形成的植入物。该植入物包括可生物降解的热塑性聚合物、具有亲核基团的生物活性剂和稳定剂以及其他可选组分。稳定剂与生物活性剂的组合可以防止、最小化和/或减轻生物活性剂对热塑性聚合物的降解。
• Biodegradable film dressing and method for its formation
  申请人：ATRIX LABORATORIES, INC.

  公开号：EP0560014A1

  公开（公告）日：1993-09-15

  The invention is directed to a biodegradable film dressing with or without additional therapeutic agents, an apparatus for spray delivery and a method for formation of the film dressing on a human or animal tissue. The film dressing is formed from a liquid composition of at least one biodegradable/bioerodible thermoplastic polymer in a pharmaceutically acceptable solvent. The spray apparatus includes a vessel containing the liquid composition with a dispensing means. The film is formed by dispensing, preferably by spraying, the liquid composition onto a tissue site and contacting the liquid composition with an aqueous based fluid to coagulate or solidify the film onto the human or animal tissue. The biodegradable film can be used to protect and to promote healing of injured tissue and/or to deliver biologically active agents.

  本发明涉及一种可生物降解的薄膜敷料，包括或不包括额外的治疗剂、一种喷雾给药装置和一种在人体或动物组织上形成薄膜敷料的方法。薄膜敷料由至少一种可生物降解/可生物降解热塑性聚合物的液体组合物在药学上可接受的溶剂中形成。喷雾装置包括一个装有液体组合物的容器和一个分配装置。形成薄膜的方法是：将液体组合物喷洒到组织部位，然后将液体组合物与水基流体接触，使薄膜凝固或固化在人体或动物组织上。可生物降解薄膜可用于保护和促进受伤组织的愈合和/或输送生物活性剂。
• Heat activatable adhesive composition and adhesive sheet having adhesive layer thereof
  申请人：Ricoh Company, Ltd.

  公开号：EP1085069A1

  公开（公告）日：2001-03-21

  A heat activatable adhesive composition including a thermoplastic resin, and a hindered phenol compound which is solid at 20°C and which is fusible at an elevated temperature. The adhesive composition is useful as a heat activatable adhesive layer of labels or sheets including a heat-sensitive recording label.

  一种可热激活的粘合剂组合物，包括热塑性树脂和受阻酚化合物，在 20°C 时为固态，在高温下可熔化。这种粘合剂组合物可用作包括热敏记录标签在内的标签或薄片的热活化粘合层。
• Composite sheet, method of preparing same, and adhesive label sheet
  申请人：Ricoh Company Ltd.

  公开号：EP1323863A1

  公开（公告）日：2003-07-02

  A composite sheet including a paper layer made of a wood pulp having a Canadian standard freeness value of 350 to 500 ml, a transparency improving layer provided over one side of the paper layer, and a release liner provided over the transparency improving layer. The composite sheet has a transmittance of at least 10 to 20 % for a light with a wavelength of 940 to 960 nm and a bulk density of 0.90 to 1.15 g/cm3. A thermosensitive recording adhesive label sheet has the above composite sheet and a thermosensitive recording sheet provided on the composite sheet through an adhesive layer.

  一种复合片材，包括由加拿大标准白度值为 350 至 500 毫升的木浆制成的纸层、覆盖在纸层一侧的透明度改进层以及覆盖在透明度改进层上的离型纸。该复合纸张对波长为 940 至 960 纳米的光的透射率至少为 10%至 20%，体积密度为 0.90 至 1.15 克/立方厘米。一种热敏记录粘合标签片材具有上述复合片材和通过粘合层设置在复合片材上的热敏记录片材。
• Acrylic films prepared by coating methods
  申请人：EASTMAN KODAK COMPANY

  公开号：EP1375573A2

  公开（公告）日：2004-01-02

  A method of film fabrication is taught that uses a coating and drying apparatus to fabricate resin films suitable for optical applications. In particular, acrylic films are prepared by simultaneous application of multiple liquid layers to a moving carrier substrate. After solvent removal, the acrylic films are peeled from the sacrificial carrier substrate. Acrylic films prepared by the current invention exhibit good clarity and low birefringence.

  本发明传授了一种薄膜制造方法，该方法使用涂布和干燥设备来制造适用于光学应用的树脂薄膜。具体而言，丙烯酸薄膜的制备方法是在移动的载体基底上同时涂上多层液体。去除溶剂后，从牺牲载体基底上剥离丙烯酸薄膜。本发明制备的丙烯酸薄膜具有良好的透明度和低双折射。