3-Chloro-5-ethoxy-4-methoxybenzaldehyde | 736948-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Chloro-5-ethoxy-4-methoxybenzaldehyde
• CAS: 736948-97-3
• 化学式: C₁₀H₁₁ClO₃
• mdl: MFCD02256401
• 分子量: 214.649
• InChiKey: KBTYBYHNPJXGES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methoxyacetohydrazide 、 3-Chloro-5-ethoxy-4-methoxybenzaldehyde 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 N-[(E)-(3-chloro-5-ethoxy-4-methoxyphenyl)methylideneamino]-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methoxyacetamide
  参考文献：
  名称：

  Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia

  摘要：

  A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.07.007

文献信息

• Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia
  作者：Neil S. Cutshall、Rene Onrust、Alex Rohde、Sasha Gragerov、Lauren Hamilton、Kevin Harbol、Hui-Rong Shen、Shawn McKee、Charles Zuta、Galina Gragerova、Vince Florio、Thomas N. Wheeler、Jennifer L. Gage

  DOI：10.1016/j.bmcl.2012.07.007

  日期：2012.9

  A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model. (C) 2012 Elsevier Ltd. All rights reserved.