1-Benzyl-2,3-dimethyl-aziridine | 222836-03-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Benzyl-2,3-dimethyl-aziridine
• 英文别名: Aziridine, 1-benzyl-2,3-dimethyl-, trans-；1-benzyl-2,3-dimethylaziridine
• CAS: 222836-03-5
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: BFXNQCMCFIVUFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Benzyl-2,3-dimethyl-aziridine 在 tin(II) trifluoromethanesulfonate 、 叠氮基三甲基硅烷 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以71%的产率得到((1R,2R)-2-Azido-1-methyl-propyl)-benzyl-amine
  参考文献：
  名称：

  An efficient method for opening nonactivated aziridines with TMS azide: application in the synthesis of chiral 1,2-diaminocyclohexane

  摘要：

  A variety of N-substituted aziridines have been opened with TMS azide in MeCN at rt in the absence of any Lewis acid. The reaction was extended to the synthesis of (R,R)- and (S,S)-1,2-diaminocyclohexane. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01793-7
• 作为产物：
  描述：

  3-[(phenylmethyl)amino]-2-butanol 在 吡啶 、 甲基磺酰氯 、 三乙胺 作用下， 生成 1-Benzyl-2,3-dimethyl-aziridine
  参考文献：
  名称：

  Mild and Efficient Method for Regioselective Ring Opening of Aziridines with Amines by Bismuth Trichloride

  摘要：

  DOI：

  10.1081/scc-120015808

文献信息

• Silica gel induced cleavage of aziridines by aromatic amines under solvent free conditions
  作者：R.Vijaya Anand、Ghanshyam Pandey、Vinod K. Singh

  DOI：10.1016/s0040-4039(02)00727-x

  日期：2002.5

  A variety of aziridines were opened in an efficient manner with aromatic amines using silica gel under solvent free conditions.

  使用无溶剂条件下的硅胶，可以用芳香胺有效地打开各种氮丙啶。
• Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
  申请人：Epigenomics AG

  公开号：EP2280084A1

  公开（公告）日：2011-02-02

  Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.

  特定方面提供了新颖的方法和组合物（如核酸、试剂盒等），这些方法和组合物在提供前列腺细胞增生性疾病的预后方面具有重要作用。在特定方面，这是通过分析一组基因或其子组的表达状态来实现的。
• Efficient Method for Cleavage of Aziridines with Aromatic Amines
  作者：Govindasamy Sekar、Vinod K. Singh

  DOI：10.1021/jo981869r

  日期：1999.4.1
• [EN] ENANTIOSELECTIVE SYNTHESIS OF AMINOTROPANE COMPOUND<br/>[FR] SYNTHÈSE ÉNANTIOSÉLECTIVE D'UN COMPOSÉ AMINOTROPANE
  申请人：[en]THERAVANCE BIOPHARMA R&D IP, LLC

  公开号：WO2022241188A1

  公开（公告）日：2022-11-17

  The present disclosure provides processes for preparing fert-butyl (1 R,3s,5S)-3- amino-8-azabicyclo[3.2.1]octane-8-carboxylate or a salt thereof. The present disclosure also provides enantioselective processes for preparing exo-aminotropane derivatives from tropinone oximes.
• An efficient method for opening nonactivated aziridines with TMS azide: application in the synthesis of chiral 1,2-diaminocyclohexane
  作者：M Chandrasekhar、G Sekar、Vinod K Singh

  DOI：10.1016/s0040-4039(00)01793-7

  日期：2000.12

  A variety of N-substituted aziridines have been opened with TMS azide in MeCN at rt in the absence of any Lewis acid. The reaction was extended to the synthesis of (R,R)- and (S,S)-1,2-diaminocyclohexane. (C) 2000 Elsevier Science Ltd. All rights reserved.