N-(4-aminophenyl)-N'-(4-chlorophenyl)-N'-propylurea | 93275-76-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-aminophenyl)-N'-(4-chlorophenyl)-N'-propylurea
• 英文别名: 3-(4-Aminophenyl)-1-(4-chlorophenyl)-1-propylurea
• CAS: 93275-76-4
• 化学式: C₁₆H₁₈ClN₃O
• 分子量: 303.791
• InChiKey: UDMMVSHMEVEVCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(4-aminophenyl)-N'-(4-chlorophenyl)-N'-propylurea 、 2-氯苯甲酰异氰酸酯 在 aluminum nickel 作用下， 以 乙醇 、 乙腈 为溶剂， 生成 N-(2-chlorobenzoyl)-N'-[4-{N'-(4-chlorophenyl)-N'-propylureido}phenyl]urea 、 N-(4-nitrophenyl)-N'-(4-chlorophenyl)-N'-propylurea
  参考文献：
  名称：

  Insecticidal and acaricidal composition comprising a benzoylurea compound

  摘要：

  本发明涉及一种杀虫和杀螨组合物，其包括一种苯甲酰脲化合物，其通式为##STR1##其中，R.sub.1是卤素原子，R.sub.2是氢原子、甲氧基或卤素原子，R.sub.3是氢原子或代表从卤素、甲基和三氟甲基中选择的1或2个取代基，R.sub.4是氢原子或代表从卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4卤代烷基和C.sub.1-C.sub.4卤代烷氧基中选择的1-3个取代基，X是氧原子或硫原子，n为0或1，R.sub.5是氢原子、C.sub.1-C.sub.6烷基、C.sub.2-C.sub.6烯基或C.sub.3-C.sub.6环烷基，但如果n为0且R.sub.5为氢原子，则R.sub.3为氢原子。该组合物可用于以每公顷1至5,000克活性物质的剂量控制昆虫和/或螨。

  公开号：

  US04710516A1

文献信息

• Insecticidal and acaricidal composition comprising a benzoylurea compound
  申请人：Duphar International Research B.V.

  公开号：US04710516A1

  公开（公告）日：1987-12-01

  The invention relates to an insecticidal and acaricidal composition comprising a benzoylurea compound of the general formula ##STR1## wherein R.sub.1 is a halogen atom, R.sub.2 is a hydrogen atom, a methoxy group or a halogen atom, R.sub.3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen, methyl and trifluoromethyl, R.sub.4 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl and C.sub.1 -C.sub.4 haloalkoxy, X is an oxygen atom or a sulphur atom, n is 0 or 1, and R.sub.5 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.2 -C.sub.6 alkenyl group or a C.sub.3 -C.sub.6 cycloalkyl group, with the proviso, that, if n is 0 and R.sub.5 is a hydrogen atom, R.sub.3 is a hydrogen atom. The composition may be used for the control of insects and/or mites in a dosage of 1 to 5,000 grams of active substance per hectare.

  本发明涉及一种杀虫和杀螨组合物，其包括一种苯甲酰脲化合物，其通式为##STR1##其中，R.sub.1是卤素原子，R.sub.2是氢原子、甲氧基或卤素原子，R.sub.3是氢原子或代表从卤素、甲基和三氟甲基中选择的1或2个取代基，R.sub.4是氢原子或代表从卤素、C.sub.1-C.sub.4烷基、C.sub.1-C.sub.4烷氧基、C.sub.1-C.sub.4卤代烷基和C.sub.1-C.sub.4卤代烷氧基中选择的1-3个取代基，X是氧原子或硫原子，n为0或1，R.sub.5是氢原子、C.sub.1-C.sub.6烷基、C.sub.2-C.sub.6烯基或C.sub.3-C.sub.6环烷基，但如果n为0且R.sub.5为氢原子，则R.sub.3为氢原子。该组合物可用于以每公顷1至5,000克活性物质的剂量控制昆虫和/或螨。
• Benzoylurea compounds and pesticidal compositions comprisingsame
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0116729A2

  公开（公告）日：1984-08-29

  The invention relates to new benzoylurea compounds of the general formula wherein R1 is a halogen atom, R2 is a hydrogen atom or a halogen atom, R3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluormethyl, R4 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy, having 1-4 carbon atoms, X is N or CH, n is 0 or 1, and R5 is a hydrogen atom, an alkyl group having 1-6 carbon atoms, an alkenyl group having 2-6 carbon atoms, or a cycloalkyl group having 3-6 carbon atoms, with the proviso, that, if n is 0 and Rs is a hydrogen atom, R3 is a hydrogen atom. The compounds have an -insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage of 1 to 5000 grams of active substance per hectare. In addition the compounds have an antitumor activity and may be used in pharmaceutical compositions.

  本发明涉及通式如下的新苯甲酰脲化合物 式中 R1 是卤素原子 R2 是氢原子或卤素原子 R3是氢原子或代表1或2个取代基，这些取代基选自氯、甲基和三氟甲基组成的组、 R4 是氢原子，或代表 1-3 个取代基，这些取代基可从具有 1-4 个碳原子的卤素、烷基、烷氧基、卤代烷基和卤代烷氧基组成的组中选出、 X 是 N 或 CH、 n 是 0 或 1，以及 R5 是氢原子、具有 1-6 个碳原子的烷基、具有 2-6 个碳原子的烯基或具有 3-6 个碳原子的环烷基，但如果 n 为 0 且 Rs 为氢原子，则 R3 为氢原子。 这些化合物具有杀虫和杀螨活性。在加工成组合物后，化合物可用于防治昆虫和/或螨虫，每公顷用量为 1 至 5000 克活性物质。此外，该化合物还具有抗肿瘤活性，可用于药物组合物中。
• US4665235A
  申请人：——

  公开号：US4665235A

  公开（公告）日：1987-05-12
• US4710516A
  申请人：——

  公开号：US4710516A

  公开（公告）日：1987-12-01
• Benzoylurea compounds, and pesticidal and pharmaceutical compositions
  申请人：Duphar International Research B.V.

  公开号：US04665235A1

  公开（公告）日：1987-05-12

  The invention relates to new benzoylurea compounds of the general formula ##STR1## wherein R.sub.1 is a halogen atom, R.sub.2 is a hydrogen atom or a halogen atom, R.sub.3 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluormethyl, R.sub.4 is a hydrogen atom or represents 1-3 substituents which are selected from the group consisting of halogen, and alkyl, alkoxy, haloalkyl and haloalkoxy, having 1-4 carbon atoms, X is N or CH, n is 0 or 1, and R.sub.5 is a hydrogen atom, an alkyl group having 1-6 carbon atoms, an alkenyl group having 2-6 carbon atoms, or a cycloalkyl group having 3-6 carbon atoms, with the proviso, that, if n is 0 and R.sub.5 is a hydrogen atom, R.sub.3 is a hydrogen atom. The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage of 1 to 5000 grams of active substance per hectare. In addition the compounds have an antitumor activity and may be used in pharmaceutical compositions.

  本发明涉及一种新的苯甲酰脲类化合物，其一般式为##STR1## 其中R.sub.1是卤素原子，R.sub.2是氢原子或卤素原子，R.sub.3是氢原子或表示1或2个取代基，所述取代基选择自氯、甲基和三氟甲基的群体中，R.sub.4是氢原子或表示1-3个取代基，所述取代基选择自卤素、烷基、烷氧基、卤代烷基和卤代烷氧基，所述基中含有1-4个碳原子，X是N或CH，n为0或1，R.sub.5是氢原子、具有1-6个碳原子的烷基、具有2-6个碳原子的烯基或具有3-6个碳原子的环烷基，但如果n为0且R.sub.5是氢原子，则R.sub.3是氢原子。这些化合物具有杀虫和杀螨活性。在制成组合物后，这些化合物可以在每公顷1至5000克活性物质的剂量下用于控制昆虫和/或螨类。此外，这些化合物具有抗肿瘤活性，可以用于制成药物组合物。