9-hydroxy-2-methyl-11-oxo-N-(4-propoxyphenyl)-1-azatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraene-10-carboxamide | 1354639-79-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 9-hydroxy-2-methyl-11-oxo-N-(4-propoxyphenyl)-1-azatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraene-10-carboxamide
• CAS: 1354639-79-4
• 化学式: C₂₂H₂₂N₂O₄
• 分子量: 378.428
• InChiKey: BDKGWVTYFIJZTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylate 、 对正丙氧基苯胺 在 N,N-二甲基甲酰胺 作用下， 以90%的产率得到9-hydroxy-2-methyl-11-oxo-N-(4-propoxyphenyl)-1-azatricyclo[6.3.1.04,12]dodeca-4(12),5,7,9-tetraene-10-carboxamide
  参考文献：
  名称：

  4-hydroxy-2-quinolones. 201*. Synthesis, structure, and diuretic activity of hydroxy- and alkoxy- anilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro- 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid

  摘要：

  Hydroxy- and alkoxyanilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids have been synthesized as potential diuretic agents. Features of their purification, their steric structure, and biological activity are discussed.

  DOI：

  10.1007/s10593-011-0882-1

文献信息

• 4-hydroxy-2-quinolones. 201*. Synthesis, structure, and diuretic activity of hydroxy- and alkoxy- anilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro- 1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid
  作者：I. V. Ukrainets、N. Yu. Golik、A. L. Shemchuk、V. N. Kravchenko

  DOI：10.1007/s10593-011-0882-1

  日期：2011.12

  Hydroxy- and alkoxyanilides of 6-hydroxy-2-methyl-4-oxo-2,4-dihydro-1H-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acids have been synthesized as potential diuretic agents. Features of their purification, their steric structure, and biological activity are discussed.