methyl 2-[2-[6-(dimethylamino)hexyl-methylamino]-3-naphthalen-2-yl-4H-quinazolin-4-yl]acetate | 1552315-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: methyl 2-[2-[6-(dimethylamino)hexyl-methylamino]-3-naphthalen-2-yl-4H-quinazolin-4-yl]acetate
• CAS: 1552315-56-6
• 化学式: C₃₀H₃₈N₄O₂
• 分子量: 486.657
• InChiKey: LLFJTGQXNLPMSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-[2-[6-(dimethylamino)hexyl-methylamino]-3-naphthalen-2-yl-4H-quinazolin-4-yl]acetate 、 苄胺 在 1,5,7-三氮杂双环[4.4.0]癸-5-烯 作用下， 反应 3.0h， 生成 BK10030
  参考文献：
  名称：

  Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist

  摘要：

  The anti-proliferative and apoptotic activities of new T-type calcium channel antagonist, 6e (BK10040) on human lung adenocarcinoma A549 cells were investigated. The MTT assay results indicated that BK10040 was cytotoxic against human lung adenocarcinoma (A549) and pancreatic cancer (MiaPaCa2) cells in a dose-dependent manner with IC50 of 2.25 and 0.93 mu M, respectively, which is ca. 2-fold more potent than lead compound KYS05090 despite of its decreased T-type calcium channel blockade. As a mode of action for cytotoxic effect of BK10040 on lung cancer (A549) cells, this cancer cell death was found to have the typical features of apoptosis, as evidenced by the accumulation of positive cells for annexin V. In addition, BK10040 triggered the activations of caspases 3 and 9, and the cleavages of poly (ADP-ribose) polymerase (PARP). Moreover, the treatment with z-VAD-fmk (a broad spectrum caspase inhibitor) significantly prevented BK10040-induced apoptosis. Based on these results, BK10040 may be used as a potential therapeutic agent for human lung cancer via the potent apoptotic activity. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.01.071
• 作为产物：
  描述：

  N,N'-二甲基-1,6-己二胺 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 甲醇 、 甲苯 为溶剂， 反应 18.0h， 生成 methyl 2-[2-[6-(dimethylamino)hexyl-methylamino]-3-naphthalen-2-yl-4H-quinazolin-4-yl]acetate
  参考文献：
  名称：

  Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist

  摘要：

  The anti-proliferative and apoptotic activities of new T-type calcium channel antagonist, 6e (BK10040) on human lung adenocarcinoma A549 cells were investigated. The MTT assay results indicated that BK10040 was cytotoxic against human lung adenocarcinoma (A549) and pancreatic cancer (MiaPaCa2) cells in a dose-dependent manner with IC50 of 2.25 and 0.93 mu M, respectively, which is ca. 2-fold more potent than lead compound KYS05090 despite of its decreased T-type calcium channel blockade. As a mode of action for cytotoxic effect of BK10040 on lung cancer (A549) cells, this cancer cell death was found to have the typical features of apoptosis, as evidenced by the accumulation of positive cells for annexin V. In addition, BK10040 triggered the activations of caspases 3 and 9, and the cleavages of poly (ADP-ribose) polymerase (PARP). Moreover, the treatment with z-VAD-fmk (a broad spectrum caspase inhibitor) significantly prevented BK10040-induced apoptosis. Based on these results, BK10040 may be used as a potential therapeutic agent for human lung cancer via the potent apoptotic activity. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.01.071

文献信息

• [EN] NOVEL COMPOUND, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] COMPOSÉ INÉDIT, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITION PHARMACEUTIQUE EN CONTENANT
  申请人：BORYUNG PHARM

  公开号：WO2014021591A2

  公开（公告）日：2014-02-06

  본 발명은 T-타입 칼슘 채널의 길항제로서 T-타입 칼슘채널의 기능과 관계된 장애와 질환의 치료 및 예방에 유용한 하이드로퀴나졸린 유도체에 관한 것이다. 본 발명은 또한 약학적으로 받아들여지는 이러한 화합물 유도체를 포함하는 조성물 및 이러한 화합물의 사용을 포함한다.
• Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist
  作者：Doo Li Choi、Sun Jeong Jang、Sehyeon Cho、Hye-Eun Choi、Hong-Kun Rim、Kyung-Tae Lee、Jae Yeol Lee

  DOI：10.1016/j.bmcl.2014.01.071

  日期：2014.3

  The anti-proliferative and apoptotic activities of new T-type calcium channel antagonist, 6e (BK10040) on human lung adenocarcinoma A549 cells were investigated. The MTT assay results indicated that BK10040 was cytotoxic against human lung adenocarcinoma (A549) and pancreatic cancer (MiaPaCa2) cells in a dose-dependent manner with IC50 of 2.25 and 0.93 mu M, respectively, which is ca. 2-fold more potent than lead compound KYS05090 despite of its decreased T-type calcium channel blockade. As a mode of action for cytotoxic effect of BK10040 on lung cancer (A549) cells, this cancer cell death was found to have the typical features of apoptosis, as evidenced by the accumulation of positive cells for annexin V. In addition, BK10040 triggered the activations of caspases 3 and 9, and the cleavages of poly (ADP-ribose) polymerase (PARP). Moreover, the treatment with z-VAD-fmk (a broad spectrum caspase inhibitor) significantly prevented BK10040-induced apoptosis. Based on these results, BK10040 may be used as a potential therapeutic agent for human lung cancer via the potent apoptotic activity. (C) 2014 Elsevier Ltd. All rights reserved.