5'-amino-5'-deoxy-2’,3’-O-isopropylidene adenosine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 5'-amino-5'-deoxy-2’,3’-O-isopropylidene adenosine
• 英文别名: 5’-amino-5‘-deoxy-2’,3'-O-isopropylidene-adenosine；9-[(3aR,4R,6R,6aS)-6-(aminomethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]purin-6-amine
• 化学式: C₁₃H₁₈N₆O₃
• 分子量: 306.324
• InChiKey: RGJLVQRLOVOJRF-IQEPQDSISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5'-amino-5'-deoxy-2’,3’-O-isopropylidene adenosine 在 磺酰胺 作用下， 以 水 为溶剂， 以93 %的产率得到N-(2',3'-O-isopropylidene-5'-deoxyadenosin-5'-yl)sulfamide
  参考文献：
  名称：

  [EN] FRET-BASED ASSAYS
  [FR] DOSAGES PAR FRET

  摘要：

  The present application provides compounds and methods for identifying a modulator of a protein of interest using TR-FRET donor attached to the protein of interest and a tracer containing TR-FRET acceptor.

  公开号：

  WO2023004438A2
• 作为产物：
  描述：

  2-(((3aR,4R,6R,6aR)-6-(6-氨基-9H-嘌呤-9-基)-2,2-二甲基四氢呋喃并[3,4-d][1,3]二氧代-4-基)甲基)异吲哚啉-1,3-二酮 在 一水合肼 作用下， 以 乙醇 为溶剂， 以93 %的产率得到5'-amino-5'-deoxy-2’,3’-O-isopropylidene adenosine
  参考文献：
  名称：

  [EN] FRET-BASED ASSAYS
  [FR] DOSAGES PAR FRET

  摘要：

  The present application provides compounds and methods for identifying a modulator of a protein of interest using TR-FRET donor attached to the protein of interest and a tracer containing TR-FRET acceptor.

  公开号：

  WO2023004438A2

文献信息

• [EN] BENZAMIDE ADENINE DINUCLEOSIDE COMPOUNDS AND THEIR USES<br/>[FR] COMPOSÉS DE BENZAMIDE ADÉNINE DINUCLÉOSIDE ET LEURS UTILISATIONS
  申请人：[en]INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE

  公开号：WO2024013349A1

  公开（公告）日：2024-01-18

  The inventors have now succeeded in developing compounds of Formula (I), described below, having the advantage of inhibiting NAD kinases, in particular P. aeruginosa NADK (PaNADK) enzyme, Listeria monocytogenes (LmNADK) enzyme and/or human cytosolic NADK (HsNADK) enzyme. The present invention relates to benzamide adenine dinucleoside compounds which are useful as inhibitors of NAD kinases, to pharmaceutical composition comprising such compounds, and to uses of such compounds in the treatment or prevention of bacterial infections.
• [EN] FRET-BASED ASSAYS<br/>[FR] DOSAGES PAR FRET
  申请人：[en]THE GENERAL HOSPITAL CORPORATION

  公开号：WO2023004438A2

  公开（公告）日：2023-01-26

  The present application provides compounds and methods for identifying a modulator of a protein of interest using TR-FRET donor attached to the protein of interest and a tracer containing TR-FRET acceptor.