2-Brom-5-nitroethylbenzol | 52121-40-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Brom-5-nitroethylbenzol
• 英文别名: 1-Bromo-2-ethyl-4-nitrobenzene
• CAS: 52121-40-1
• 化学式: C₈H₈BrNO₂
• 分子量: 230.061
• InChiKey: PUUCKBAMKMTQAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Brom-5-nitroethylbenzol 在 盐酸 、 铁粉 作用下， 生成 4-bromo-3-ethylaniline
  参考文献：
  名称：

  7-乙基-8-溴-10-（1'-D-ribityl）异恶嗪和7-溴-8-乙基-10-（1'-D-ribityl）异恶嗪（核黄素类似物）的合成和生物活性。

  摘要：

  DOI：

  10.1021/jm00248a018

文献信息

• CK2 INHIBITORS, COMPOSITIONS AND METHODS THEREOF
  申请人：Polaris Pharmaceuticals

  公开号：US20170369489A1

  公开（公告）日：2017-12-28

  The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. For Formula (I) compounds R 1 , R 2 , R 3 , Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

  本发明提供了根据式（I）的化合物的合成、药用可接受的配方和用途，或其立体异构体、互变异构体或药用可接受的盐。对于式（I）化合物，R1、R2、R3、Ar和Z的定义如规范中所述。这种创新的式（I）化合物是CK2的抑制剂，在许多治疗应用中发挥作用，包括但不限于治疗增生性疾病，如癌症、炎症和免疫性疾病。
• BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：Katayama Seiji

  公开号：US20130116227A1

  公开（公告）日：2013-05-09

  Disclosed is a novel biaryl amide derivative represented by formula (1) and having an affinity for the aldosterone receptor; also disclosed is a pharmaceutically acceptable salt thereof. (In the formula, A is any of the groups represented by formula (a); L is —CONH—, etc.; R 1 is a substitutable aminosulfonyl group, etc.; R 2 is a hydrogen atom, etc.; R 3 is a hydrogen atom, etc.; R 4 is a hydrogen atom, a halogen atom, hydroxy group, a substitutable amino group, a substitutable C 1-6 alkoxy group, a substitutable 4- to 7-membered cyclic amino group, etc.; R 5a , R 5b and R 5c are each independently hydrogen atoms, etc.; R 6 is a halogen atom, a cyano group, etc.; R 7 and R 8 are each independently a hydrogen atom, etc.; and m is an integer such as 0.)

  揭示了一种表示为公式（1）的新型联苯酰胺衍生物，具有与醛固酮受体的亲和力；还揭示了其药用可接受的盐。（在该公式中，A是由公式（a）表示的任何基团之一；L是—CONH—等；R1是可替代的氨基磺酰基等；R2是氢原子等；R3是氢原子等；R4是氢原子、卤原子、羟基、可替代的氨基基团、可替代的C1-6烷氧基、可替代的4-到7-成员环氨基基团等；R5a、R5b和R5c各自独立地是氢原子等；R6是卤原子、氰基等；R7和R8各自独立地是氢原子等；m是整数，例如0。）
• Novel Specific Caspase-10 Inhibitors
  申请人：Lardy Claude

  公开号：US20080255173A1

  公开（公告）日：2008-10-16

  The invention relates to compounds of the general formula (I), and to their use as caspase-10 inhibitors, especially for the treatment of diabetic retinopathy.

  本发明涉及通式(I)的化合物及其作为caspase-10抑制剂的用途，尤其是用于治疗糖尿病视网膜病变。
• BIS-QUARTERNARY CINCHONA ALKALOID SALTS AS ASYMMETRIC PHASE TRANSFER CATALYSTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150031891A1

  公开（公告）日：2015-01-29

  The invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. The present invention is directed to novel bis-quarternary cinchona alkaloid salts and the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis. On certain substrates and under specific reaction conditions, the inventors have discovered that the use of bis-quarternary cinchona alkaloid salts in asymmetric phase transfer catalysis surprisingly provides for a more active and efficient process as compared to mono-quarternary catalysts.

  本发明涉及新型的双季铵喜树碱盐以及在不对称相转移催化中使用双季铵喜树碱盐。本发明涉及新型的双季铵喜树碱盐以及在不对称相转移催化中使用双季铵喜树碱盐。在某些底物和特定反应条件下，发明人发现与单季铵催化剂相比，使用双季铵喜树碱盐在不对称相转移催化中出人意料地提供了更活跃和高效的过程。
• US7829721B2
  申请人：——

  公开号：US7829721B2

  公开（公告）日：2010-11-09