(10Z,13Z)-octadeca-10,13-dienoyl chloride

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: (10Z,13Z)-octadeca-10,13-dienoyl chloride
• 化学式: C₁₈H₃₁ClO
• 分子量: 298.897
• InChiKey: BGHKWOJCJAYMNI-AFJQJTPPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.57
• 重原子数：
  20.0
• 可旋转键数：
  14.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-1-(3,4-二氟苯基)-N-羟基甲亚胺 、 (10Z,13Z)-octadeca-10,13-dienoyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以24%的产率得到[(E)-(3,4-difluorophenyl)methylideneamino] (10Z,13Z)-octadeca-10,13-dienoate
  参考文献：
  名称：

  (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors

  摘要：

  A series of (E)-phenyl- and -heteroaryl- substituted O-benzoyl-(or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A(2) (Lp-PLA(2)) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2. (c) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.11.063

文献信息

• (E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors
  作者：Tae-Sook Jeong、Mi Jeong Kim、Hana Yu、Kyung Soon Kim、Joong-Kwon Choi、Sung-Soo Kim、Woo Song Lee

  DOI：10.1016/j.bmcl.2004.11.063

  日期：2005.3

  A series of (E)-phenyl- and -heteroaryl- substituted O-benzoyl-(or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A(2) (Lp-PLA(2)) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2. (c) 2004 Elsevier Ltd. All rights reserved.