2,2,2-Trifluor-1-(4-chlor-phenyl)-1-(4-methoxy-phenyl)-ethanol-1 | 1651-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2,2-Trifluor-1-(4-chlor-phenyl)-1-(4-methoxy-phenyl)-ethanol-1
• 英文别名: 1-(4-chlorophenyl)-2,2,2-trifluoro-1-(4-methoxyphenyl)ethanol；1-(4-Chlorophenyl)-2,2,2-trifluoro-1-(4-methoxyphenyl)ethanol
• CAS: 1651-69-0
• 化学式: C₁₅H₁₂ClF₃O₂
• 分子量: 316.707
• InChiKey: CMMHEIFLSCSECN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4'-氯-2,2,2-三氟苯乙酮 、 4-甲氧基苯硼酸 在 sSPhos 、 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 24.0h， 以95%的产率得到2,2,2-Trifluor-1-(4-chlor-phenyl)-1-(4-methoxy-phenyl)-ethanol-1
  参考文献：
  名称：

  The rhodium-catalysed 1,2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos

  摘要：

  The rhodium-catalysed 1,2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.10.082

文献信息

• The rhodium-catalysed 1,2-addition of arylboronic acids to aldehydes and ketones with sulfonated S-Phos
  作者：James R. White、Gareth J. Price、Pawel K. Plucinski、Christopher G. Frost

  DOI：10.1016/j.tetlet.2009.10.082

  日期：2009.12

  The rhodium-catalysed 1,2-addition of arylboronic acids to aryl aldehydes has been accomplished in high yield using sulfonated S-Phos, a water-soluble biaryl phosphine ligand which allows for catalyst recycling. The catalytic protocol has also been successful in the challenging arylation of ketones. (C) 2009 Elsevier Ltd. All rights reserved.