US10023543, Example 1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: US10023543, Example 1
• 英文别名: 4-[2-(4-aminopiperidin-1-yl)-1-methyl-5-(4-methylphenyl)-6-oxopyrimidin-4-yl]benzonitrile
• 化学式: C₂₄H₂₅N₅O
• 分子量: 399.5
• InChiKey: KFFPAIUTQJYMTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  85.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] TREATMENT OF RELAPSED AND/OR REFRACTORY SOLID TUMORS AND NON-HODGKIN'S LYMPHOMAS<br/>[FR] TRAITEMENT DE TUMEURS SOLIDES RÉCIDIVANTES ET/OU RÉFRACTAIRES ET DE LYMPHOMES NON HODGKINIENS.
  申请人：CELGENE CORP

  公开号：WO2018031658A1

  公开（公告）日：2018-02-15

  Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).

  提供了一种治疗复发和/或难治性实体肿瘤（包括神经内分泌癌（NEC）和非霍奇金淋巴瘤（NHL）等）的方法，使用替代杂环衍生物化合物和包含用于抑制赖氨酸特异性去甲基化酶-1（LSD-1）的化合物的药物组合物。
• INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
  申请人：Quanticel Pharmaceuticals, Inc.

  公开号：US20160130247A1

  公开（公告）日：2016-05-12

  The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.

  本发明涉及治疗癌症和肿瘤性疾病的组合物和方法。提供了取代杂环衍生物化合物和包含该化合物的制药组合物。所述化合物和组合物对于抑制赖氨酸特异性去甲基化酶-1具有用途。此外，所述化合物和组合物对于治疗癌症具有用途。
• Inhibitors of lysine specific demethylase-1
  申请人：CELGENE QUANTICEL RESEARCH, INC.

  公开号：US10023543B2

  公开（公告）日：2018-07-17

  The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer.

  本发明一般涉及治疗癌症和肿瘤性疾病的组合物和方法。本发明提供了取代的杂环衍生物化合物和包含所述化合物的药物组合物。所述化合物和组合物可用于抑制赖氨酸特异性去甲基化酶-1。此外，所述化合物和组合物还可用于治疗癌症。
• Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas
  申请人：CELGENE CORPORATION

  公开号：US10328077B2

  公开（公告）日：2019-06-25

  Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).

  提供了使用取代杂环衍生物化合物和药物组合物治疗复发性和/或难治性实体瘤（包括神经内分泌癌（NEC））和非霍奇金淋巴瘤（NHL）等的方法，这些化合物和药物组合物包含可用于抑制赖氨酸特异性去甲基化酶-1（LSD-1）的化合物。
• Treatment of relapsed and/or refractory solid tumors and non-Hodgkin's lymphomas
  申请人：CELGENE QUANTICEL RESEARCH, INC.

  公开号：US10548896B2

  公开（公告）日：2020-02-04

  Methods are provided for the treatment of relapsed and/or refractory solid tumors (including neuroendocrine carcinomas (NEC)) and non-Hodgkin's lymphomas (NHLs) and the like, using substituted heterocyclic derivative compounds and pharmaceutical compositions comprising compounds useful for the inhibition of lysine specific demethylase-1 (LSD-1).

  提供了使用取代杂环衍生物化合物和药物组合物治疗复发性和/或难治性实体瘤（包括神经内分泌癌（NEC））和非霍奇金淋巴瘤（NHL）等的方法，这些化合物和药物组合物包含可用于抑制赖氨酸特异性去甲基化酶-1（LSD-1）的化合物。