N-(cyanomethyl)benzanilide | 14101-08-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(cyanomethyl)benzanilide
• 英文别名: N-benzoyl-N-phenylaminoacetonitrile；N-(cyanomethyl)-N-phenylbenzamide；(N-Benzoylanilino)-acetonitril；N-benzoyl-N-phenyl-glycine nitrile；N-Benzoyl-N-phenyl-glycin-nitril
• CAS: 14101-08-7
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: QGODDVPXQWOZKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(cyanomethyl)benzanilide 在 盐酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 21.5h， 生成 N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-N-phenyl-benzamide
  参考文献：
  名称：

  Aminoamidines

  摘要：

  2-(Arylaminomethyl)imidazolines were prepared by the reaction of arylaminoacetonitriles with ethylenediamine in the presence of catalytic amounts of P2S5 These imidazolines react with aroyl chlorides (1 : 2 ratio) to give diacylation products. In the case of a 1 : 1 mole ratio as well as on treatment with Ac2O in Et(3)N, monoacylation at the imidazoline ring predominantly occurs. Isomeric 2-(N-benzoyl-N-arylaminomethyl)imidazolines were obtained from N-benzoyl-N-arylaminoacetonitriles by the Pinner method. 2-(N-Aroyl-N-arylaminomethyl)benzimidazoles and -benzoxazoles were synthesized in a similar way.

  DOI：

  10.1007/bf01169722
• 作为产物：
  描述：

  苯胺基乙腈 、 苯甲酰氯 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以96%的产率得到N-(cyanomethyl)benzanilide
  参考文献：
  名称：

  通过钯（II）催化的CC偶联和CN缩合级联反应可控制地访问多取代的咪唑

  摘要：

  通过级联钯催化的CC偶合反应，然后形成分子内CN键，可随意合成各种2,4-二取代，1,2,4-三取代和1,2,4,5-四取代的咪唑的新颖有效的方法发展了。首先报道了容易获得的硼酸和N-取代的2-氨基乙腈，是制备二，三和四取代的咪唑的起始原料，其产率高至优异。

  DOI：

  10.1039/c7cc05315k

文献信息

• Method and devices for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries
  申请人：——

  公开号：US20020006672A1

  公开（公告）日：2002-01-17

  According to the inventive method for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries, the substances are first embedded in a matrix consisting of at least one solvent, said solvent being in a solid state of aggregation at a temperature below 90° C., preferably below 50° C. The substances that are embedded in the matrix from transport units which are subsequently applied to the support in a solid state of aggregation, at a temperature below 90° C., preferably below 50° C. Alternatively, the transport units can be dissolved with a second solvent part and applied to the support in a liquid state of aggregation, where they adopt a solid or gel-like stage of aggregation after said solvent part has completely or partially evaporated. The substances on the matrix are then mobilized by modifying their physical environment and brought into the vicinity of the support surface through a physical process. Here, the substances link up with the molecules. This method can be repeated to apply multiple layers to the support in precise positions. The method can be carried out using a device which essentially has the structure of a laser printer or a laser copier or an ink-jet printer.

  根据本发明将物质应用到载体上的方法，特别是用于分子库组合合成的单体，首先将物质包埋在由至少一种溶剂组成的基质中，所述溶剂在低于90°C，最好低于50°C的温度下处于固态聚集状态、嵌入基质中的物质由传输单元组成，这些传输单元随后在低于 90 摄氏度（最好低于 50 摄氏度）的固态聚集状态下被施加到载体上。然后，基质上的物质通过改变其物理环境被调动起来，并通过物理过程被带到支撑物表面附近。在此，物质与分子连接起来。这种方法可以重复使用，以便在支撑物的精确位置上涂抹多层。这种方法可以使用一种基本上具有激光打印机、激光复印机或喷墨打印机结构的设备来实现。
• Synthetic uses of open-chain analogs of Reissert compounds
  作者：William E. McEwen、Anthony V. Grossi、Russell J. MacDonald、Andrew P. Stamegna

  DOI：10.1021/jo01295a027

  日期：1980.3
• Friedrich, Klaus; Zamkanei, Mohebullah; Zimmer, Ralph, Advanced Synthesis and Catalysis, 2000, vol. 342, # 4, p. 404 - 408
  作者：Friedrich, Klaus、Zamkanei, Mohebullah、Zimmer, Ralph

  DOI：——

  日期：——
• Nature of the Organic Base in Reissert Compounds¹
  作者：I. W. Elliott

  DOI：10.1021/ja01621a067

  日期：1955.8
• ONE-POT SYNTHESIS OF PENTASUBSTITUTED PYRROLES FROM TERTIARY AMIDES AND MALONONITRILE VIA AN INDIRECT CONDENSATION REACTION ON AMIDIC CARBONYL GROUP
  作者：Georgia Tsolomiti、Kyriaki Tsolomiti、Athanase Tsolomitis

  DOI：10.1515/hc.2007.13.4.235

  日期：2007.1